CIQUP-IMS/Department of Chemistry & Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre 687, Porto, 4169-007, Portugal.
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Future Med Chem. 2023 Jan;15(2):211-224. doi: 10.4155/fmc-2022-0243. Epub 2023 Feb 21.
Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicinal chemistry and chemical biology. Its particular reactivity has traditionally popularized the preparation of propargylamine derivatives using a large variety of synthetic strategies, which have facilitated the access to these compounds for the study of their biomedical potential. This review comprehensively covers and analyzes the applications that propargylamine-based derivatives have achieved in the drug discovery field, both from a medicinal chemistry perspective and from a chemical biology-oriented approach. The principal therapeutic fields where propargylamine-based compounds have made an impact are identified, and a discussion of their influence and growing potential is included.
炔丙胺是一种化学基团，其性质使其在药物化学和化学生物学领域中广泛分布。其独特的反应性使得使用各种合成策略来制备炔丙胺衍生物变得非常流行，这为研究其生物医学潜力提供了这些化合物的途径。本文全面综述和分析了基于炔丙胺的衍生物在药物发现领域中的应用，从药物化学和化学生物学的角度进行了分析。确定了基于炔丙胺的化合物产生影响的主要治疗领域，并讨论了它们的影响和不断增长的潜力。
