Gibson M J, Karpinski M R, Slack R C, Cowlishaw W A, Webb J K
Spinal Research Unit, Harlow Wood Orthopaedic Hospital, Nottingham, England.
J Bone Joint Surg Br. 1987 Nov;69(5):784-6. doi: 10.1302/0301-620X.69B5.3680343.
The role of antibiotics in the treatment of disc-space infection is controversial. This study assessed the tissue penetration of flucloxacillin and cephradine into the normal intervertebral disc after intravenous administration of a bolus dose of antibiotic. Twenty-five discs were removed from 12 adolescent patients having anterior spinal surgery to correct scoliosis; antibiotic had been administered between 30 minutes and four hours before operation. Despite high blood levels, no antibiotic could be detected by bioassay or by high-pressure liquid chromatography (h.p.l.c.) in any of the specimens from the nucleus pulposus or the annulus fibrosus.
抗生素在椎间盘感染治疗中的作用存在争议。本研究评估了静脉推注抗生素后氟氯西林和头孢拉定在正常椎间盘中的组织穿透情况。从12例接受前路脊柱手术以矫正脊柱侧弯的青少年患者身上取下25个椎间盘；术前30分钟至4小时内已给予抗生素。尽管血药浓度很高，但通过生物测定或高压液相色谱法（h.p.l.c.）在来自髓核或纤维环的任何标本中均未检测到抗生素。
