Li Gan, Sng Kim Sia, Shu Bing, Wang Yong-Jun, Yao Min, Cui Xue-Jun
Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Department of Chinese Medicine, Centre for Complementary and Alternative Medicine, International Medical University, 57000, Kuala Lumpur, Malaysia.
Eur J Pharmacol. 2023 Apr 15;945:175524. doi: 10.1016/j.ejphar.2023.175524. Epub 2023 Feb 16.
Spinal cord injury (SCI) is a serious disabling condition that leads to the loss of motor, sensory, and excretory functions, seriously affecting the quality of life of patients and imposing a heavy burden on the patient's family and society. There is currently a lack of effective treatments for SCI. However, a large number of experimental studies have shown beneficial effects of tetramethylpyrazine (TMP). We performed a meta-analysis to systematically evaluate the effects of TMP on neurological and motor function recovery in rats with acute SCI. English (PubMed, Web of Science, and EMbase) and Chinese (CNKI, Wanfang, VIP, and CBM) databases were searched for literature related to TMP treatment in rats with SCI published until October 2022. Two researchers independently read the included studies, extracted the data, and evaluated their quality. A total of 29 studies were included, and a risk of bias assessment revealed that the methodological quality of the included studies was low. The results of the meta-analysis showed that the Basso, Beattie, and Bresnahan (BBB; n = 429, pooled mean difference [MD] = 3.44, 95% confidence interval [CI] = 2.67 to 4.22, p < 0.00001) and inclined plane test (n = 133, pooled MD = 5.60, 95% CI = 3.78 to 7.41, p < 0.00001) scores of rats treated with TMP were significantly higher than those in the control group at 14 days after SCI. TMP treatment also resulted in a significant reduction in malondialdehyde (MDA; n = 128, pooled MD = -2.03, 95% CI = -3.47 to -0.58, p < 0.00001) and increased superoxide dismutase (SOD; n = 128, pooled MD = 5.02, 95% CI = 2.39 to 7.65, p < 0.00001). Subgroup analysis indicated that different doses of TMP did not improve the BBB scale and inclined plane test angles. In conclusion, this review showed that TMP can improve SCI outcomes; however, in view of the limitations of the included studies, larger and high-quality studies are required for verification.
脊髓损伤（SCI）是一种严重的致残性疾病，会导致运动、感觉和排泄功能丧失，严重影响患者的生活质量，并给患者家庭和社会带来沉重负担。目前，SCI缺乏有效的治疗方法。然而，大量实验研究表明川芎嗪（TMP）具有有益作用。我们进行了一项荟萃分析，以系统评估TMP对急性SCI大鼠神经和运动功能恢复的影响。检索了英文（PubMed、Web of Science和EMbase）和中文（CNKI、万方、维普和CBM）数据库中截至2022年10月发表的与TMP治疗SCI大鼠相关的文献。两名研究人员独立阅读纳入的研究，提取数据并评估其质量。共纳入29项研究，偏倚风险评估显示纳入研究的方法学质量较低。荟萃分析结果显示，在SCI后14天，接受TMP治疗的大鼠的Basso、Beattie和Bresnahan（BBB；n = 429，合并平均差[MD] = 3.44，95%置信区间[CI] = 2.67至4.22，p < 0.00001）评分和斜板试验（n = 133，合并MD = 5.60，95% CI = 3.78至7.41，p < 0.00001）评分显著高于对照组。TMP治疗还导致丙二醛（MDA；n = 128，合并MD = -2.03，95% CI = -3.47至-0.58，p < 0.00001）显著降低，超氧化物歧化酶（SOD；n = 128，合并MD = 5.02，95% CI = 2.39至7.65，p < 0.00001）升高。亚组分析表明，不同剂量的TMP并未改善BBB量表和斜板试验角度。总之，本综述表明TMP可以改善SCI的结果；然而，鉴于纳入研究的局限性，需要更大规模和高质量的研究进行验证。
