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采用顶空进样系统和外标法，通过气相色谱法测定药品中的残留溶剂。

Determination of residual solvents in pharmaceutical products by gas chromatography coupled to a head-space injection system and using an external standard.

作者信息

Guimbard J P, Person M, Vergnaud J P

机构信息

Sanofi Recherche, Montpellier, France.

出版信息

J Chromatogr. 1987 Aug 21;403:109-21. doi: 10.1016/s0021-9673(00)96345-3.

DOI:10.1016/s0021-9673(00)96345-3
PMID:3680405
Abstract

A method of determination of residual solvents in powders using gas chromatography with an head-space injection system has been developed. The chromatographic conditions and parameters of the injection system were optimized to enable the quantification by external standardization of most common solvents in concentrations ranging from a few ppm to a few per cent.

摘要

已开发出一种使用顶空进样系统的气相色谱法测定粉末中残留溶剂的方法。对色谱条件和进样系统参数进行了优化，以便能够通过外标法对浓度范围从几ppm到百分之几的最常见溶剂进行定量分析。

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