Division of Oncopathology,Clinical Lab Services & Translational Research, Malabar Cancer Centre, Thalassery, Kerala, India.
Dept of Head and Neck Surgery, Aster MIMS Kannur, Kerala, India.
Gulf J Oncolog. 2023 Jan;1(41):111-116.
Ghost Cell Odontogenic Carcinoma is a rare malignant odontogenic tumor that can appear as "de novo " or arises from malignant transformation of preexisting benign calcifying odontogenic cysts or dentinogenic ghost cell tumors after multiple recurrences. Ghost cell odontogenic carcinoma is histopathologically characterized by ameloblast-like islands of epithelial cells with aberrant keratinization, simulating a ghost cell, with varying amounts of dysplastic dentine. This article reports an extremely rare case of ghost cell odontogenic carcinoma with foci of sarcomatous change, involving maxilla andnasal cavity which arose from a previously existing recurrent calcifying odontogenic cysts in a 54-year-old man and reviews the features of this unusual and rare tumor. To the best of our knowledge, this is the first case of ghost cell odontogenic carcinoma with sarcomatous transformation to be reported till date. Owing to its rarity and unpredictability of clinical course, long -term follow up of patients with ghost cell odontogenic carcinoma, is mandatory for observation of recurrence and distant metastasis. Keywords: Ghost cell odontogenic carcinoma, maxilla, sarcoma, calcifying odontogenic cysts, ghost cells, odontogenic tumour.
牙源性影细胞瘤是一种罕见的恶性牙源性肿瘤，可表现为“新生物型”或由多次复发的已存在良性钙化牙源性囊肿或牙源性影细胞瘤恶变而来。牙源性影细胞瘤的组织病理学特征为上皮细胞呈成釉细胞瘤样的岛状，伴有异常角化，模拟鬼影细胞，伴有不同程度的发育不良牙本质。本文报告了一例极为罕见的上颌骨和鼻腔的牙源性影细胞瘤伴肉瘤样变的病例，该患者为 54 岁男性，源于先前存在的复发性钙化牙源性囊肿，回顾了这种不常见和罕见肿瘤的特征。据我们所知，这是迄今为止首例报道的牙源性影细胞瘤伴肉瘤样变的病例。由于其罕见性和临床病程的不可预测性，对牙源性影细胞瘤患者进行长期随访对于观察复发和远处转移是必需的。关键词：牙源性影细胞瘤、上颌骨、肉瘤、钙化牙源性囊肿、鬼影细胞、牙源性肿瘤。
