肌动蛋白最终成熟：揭示其机制与影响
Actin finally matures: uncovering machinery and impact.
作者信息
Arnesen Thomas, Aksnes Henriette
机构信息
Department of Biomedicine, University of Bergen, Bergen, Norway; Department of Biological Sciences, University of Bergen, Bergen, Norway; Department of Surgery, Haukeland University Hospital, Bergen, Norway.
Department of Biomedicine, University of Bergen, Bergen, Norway.
出版信息
Trends Biochem Sci. 2023 May;48(5):414-416. doi: 10.1016/j.tibs.2023.02.002. Epub 2023 Feb 17.
Actin, one of the most abundant proteins in nature and a key component of the cytoskeleton, undergoes a unique multistep N-terminal (Nt) maturation. In a recent report, Haahr et al. identified actin maturation protease (ACTMAP) as the dedicated actin aminopeptidase and showed that its absence is associated with abnormal muscle physiology.
肌动蛋白是自然界中最丰富的蛋白质之一，也是细胞骨架的关键组成部分，它经历独特的多步骤N端成熟过程。在最近的一份报告中，哈赫等人鉴定出肌动蛋白成熟蛋白酶（ACTMAP）是专门的肌动蛋白氨肽酶，并表明其缺失与异常的肌肉生理相关。
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