生物医学应用中的单链聚合物纳米颗粒。
Single-chain polymer nanoparticles in biomedical applications.
机构信息
Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, the Netherlands.
Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, the Netherlands.
出版信息
J Control Release. 2023 Apr;356:26-42. doi: 10.1016/j.jconrel.2023.02.019. Epub 2023 Mar 1.
Single-chain polymer nanoparticles (SCNPs) are a well-defined and uniquely sized class of polymer nanoparticles. The advances in polymer science over the past decades have enabled the development of a variety of intramolecular crosslinking systems, leading to particles in the 5-20 nm size regime. Which is aligned with the size regime of proteins and therefore making SCNPs an interesting class of NPs for biomedical applications. The high modularity of SCNP design and the ease of their functionalization have led to growing research interest. In this review, we describe different crosslinking systems, as well as the preparation of functional SCNPs and the variety of biomedical applications that have been explored.
单链聚合物纳米粒子（SCNPs）是一类具有明确且独特尺寸的聚合物纳米粒子。过去几十年来，聚合物科学的发展使得各种分子内交联系统得以开发，从而得到了尺寸在 5-20nm 范围内的粒子。这与蛋白质的尺寸范围相匹配，因此使得 SCNPs 成为生物医学应用中一类有趣的纳米粒子。SCNP 设计的高模块性和其功能化的容易程度导致了研究兴趣的增长。在这篇综述中，我们描述了不同的交联系统，以及功能性 SCNPs 的制备和已经探索过的各种生物医学应用。
Zotero 插件