Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan.
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Gastroenterology. 2023 Apr;164(5):752-765. doi: 10.1053/j.gastro.2023.02.012. Epub 2023 Feb 18.
Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicates that pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.
胰腺癌通常导致预后不良，治疗选择有限，因为大多数受影响的个体都处于疾病晚期。早期发现癌前胰腺肿瘤并确定分子治疗靶点为延长生存期提供了机会。虽然目前不建议对普通人群进行胰腺癌筛查，但新出现的证据表明，胰腺监测可以改善某些高危人群的预后。胰腺癌流行病学的变化、胰腺监测的经验以及新型生物标志物的发现为胰腺癌风险评估、早期检测和预防的新策略提供了路线图。
