Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis.
作者信息
Mohamed Fteah Asmaa, Abdel Rahim Ali, Ahmed AbdelHady Afaf, Shawky Hanan, A Elrefaiy Mohamed, Mamdouh Aly Doaa
机构信息
Clinical Chemistry Department - Theodor Bilharz Research Institute, Egypt.
Hepato-gastroentrology Department - Theodor Bilharz Research Institute, Egypt.
出版信息
Tumour Virus Res. 2023 Jun;15:200256. doi: 10.1016/j.tvr.2023.200256. Epub 2023 Feb 16.
Abstract
摘要
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1
Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis.PNPLA3（rs738409）、TM6SF2（rs58542926）及自噬相关基因16样蛋白1（ATG16L1，rs2241880）基因变异与一组埃及丙型肝炎病毒诱导的肝硬化患者肝细胞癌易感性的关联
Tumour Virus Res. 2023 Jun;15:200256. doi: 10.1016/j.tvr.2023.200256. Epub 2023 Feb 16.
2
Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.载脂蛋白基因变异与 TM6SF2 基因变异易导致酒精性肝硬化患者发生肝细胞癌。
Am J Gastroenterol. 2018 Oct;113(10):1475-1483. doi: 10.1038/s41395-018-0041-8. Epub 2018 Mar 13.
3
PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis.PNPLA3基因rs738409位点和TM6SF2基因rs58542926位点的变异增加了酒精性肝硬化患者患肝细胞癌的风险。
Dig Liver Dis. 2016 Jan;48(1):69-75. doi: 10.1016/j.dld.2015.09.009. Epub 2015 Sep 28.
4
The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis.ATG16L1 基因变异 rs2241880（p.T300A）与肝硬化患者 HCC 的易感性相关。
Liver Int. 2019 Dec;39(12):2360-2367. doi: 10.1111/liv.14239. Epub 2019 Sep 11.
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[Correlation between PNPLA3 rs738409 and TM6SF2 rs58542926 gene polymorphism and primary liver cancer in the Han Population of China's Northeast region].[PNPLA3基因rs738409位点与TM6SF2基因rs58542926位点多态性与中国东北地区汉族人群原发性肝癌的相关性]
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Evaluation of the association of a variant in PNPLA3 and TM6SF2 with fibrosis progression in patients with chronic hepatitis C infection after eradication: A retrospective study.评估 PNPLA3 和 TM6SF2 变异与慢性丙型肝炎感染患者根除后纤维化进展的相关性：一项回顾性研究。
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[Effects of PNPLA3, TM6SF2 gene polymorphisms and its interactions with smoking and alcohol drinking on hepatitis B virus-associated hepatocellular carcinoma].[PNPLA3、TM6SF2基因多态性及其与吸烟和饮酒的相互作用对乙型肝炎病毒相关肝细胞癌的影响]
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PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.载脂蛋白 L3 和跨多种病因和基础肝病严重程度的肝细胞癌风险因素 TM6SF2 变异体。
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The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.载脂蛋白 L3（PNPLA3）rs738409 148M/M 基因型是酒精性肝硬化肝癌的危险因素，但在丙型肝炎肝硬化中无关联或关联较弱。
PLoS One. 2011;6(11):e27087. doi: 10.1371/journal.pone.0027087. Epub 2011 Nov 7.
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TGF-Β1 & PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis and HCC in Egyptian Patients with HCV-Related Liver Cirrhosis.TGF-β1 和 PNPLA3 基因变异与埃及丙型肝炎相关肝硬化患者肝纤维化和 HCC 的风险。
Asian Pac J Cancer Prev. 2021 Oct 1;22(10):3317-3326. doi: 10.31557/APJCP.2021.22.10.3317.
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