Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Tulane University School of Medicine, New Orleans, LA, USA.
Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Tulane University School of Medicine, New Orleans, LA, USA.
Trends Cardiovasc Med. 2024 May;34(4):250-253. doi: 10.1016/j.tcm.2023.02.004. Epub 2023 Feb 17.
Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHADS-VASc score, the risk of thromboembolism seems to be high even in CA patients without AF. AV Nodal disease is prevalent and may precede the diagnosis of CA. The incidence of ventricular arrhythmias remains disputed, and the role of implantable cardioverter defibrillator devices in CA patients is controversial. Newer therapies targeted against specific types of CA have been developed, but their effects on conductive system disease are not well studied.
心脏淀粉样变 (CA) 对传导系统有多种有害影响。到目前为止，心房颤动 (AF) 是 CA 最常见的电生理表现，与更高的死亡率、发病率和住院率相关。尽管无论 CHADS-VASc 评分如何，AF 都会增加血栓形成的风险，但即使在没有 AF 的 CA 患者中，血栓栓塞的风险似乎也很高。房室结疾病很常见，并且可能先于 CA 的诊断。室性心律失常的发生率仍存在争议，植入式心脏复律除颤器 (ICD) 在 CA 患者中的作用也存在争议。针对特定类型 CA 的新型靶向治疗已经被开发出来，但它们对传导系统疾病的影响尚未得到很好的研究。
