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Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats.

作者信息

Luo Yuanyuan, Li Li, Wang Lele, Shang Pingping, Pan Defeng, Liu Yang, Xu Tongda, Li Dongye

机构信息

Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, China.

Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.

出版信息

Chin Med J (Engl). 2023 Apr 5;136(7):866-867. doi: 10.1097/CM9.0000000000002389.

DOI:10.1097/CM9.0000000000002389
PMID:36805547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10150893/
Abstract
摘要

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Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats.在大鼠中，木犀草素预处理后，微小RNA-23a的下调通过上调组织因子途径抑制剂2赋予对心肌缺血/再灌注损伤的保护作用。
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2
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Luteolin alleviates cardiac ischemia/reperfusion injury in the hypercholesterolemic rat via activating Akt/Nrf2 signaling.木犀草素通过激活 Akt/Nrf2 信号通路减轻高脂血症大鼠的心肌缺血/再灌注损伤。
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Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury.木犀草素抑制心肌缺血/再灌注损伤中 ROS 激活的 MAPK 通路。
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SHP-1/STAT3 Interaction Is Related to Luteolin-Induced Myocardial Ischemia Protection.SHP-1/STAT3 相互作用与木犀草素诱导的心肌缺血保护有关。
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Luteolin confers renoprotection against ischemia-reperfusion injury via involving Nrf2 pathway and regulating miR320.木犀草素通过涉及 Nrf2 途径和调节 miR320 发挥对缺血再灌注损伤的肾保护作用。
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Cardioprotective effects of luteolin on ischemia/reperfusion injury in diabetic rats are modulated by eNOS and the mitochondrial permeability transition pathway.木犀草素对糖尿病大鼠缺血/再灌注损伤的心脏保护作用受内皮型一氧化氮合酶和线粒体通透性转换途径调节。
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