Xu Peng, Zhang Fan, Cheng Jinqun, Huang Yanhong, Ren Zhiqiang, Ye Rongrong, Fan Jingyi, Li Lixia, Gao Yanhui
Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510220, China.
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
J Affect Disord. 2023 May 1;328:108-115. doi: 10.1016/j.jad.2023.02.045. Epub 2023 Feb 16.
Studies have shown that subjective cognitive decline (SCD) is a major risk factor for mild cognitive impairment or even dementia, but the relationship between physical activity (PA) and SCD is still unclear. The goal of current study is to address how various physical activities relate to SCD.
216,593 adults from the Behavioral Risk Factor Surveillance System (BRFSS) were included in this study. We measured SCD and PA with participants' self-report. With the unconditional logistic regression model, the association between PA and SCD was investigated. We used a four-way decomposition method to explore the mediation roles of depression between PA and SCD. The nearest matching method of propensity score and multinomial propensity score were used to reduce the effects of confounding factors.
Compared with those inactive, the weighted adjusted odds ratios (AORs) of SCD among those who were physically active were <1 (p < 0.005), regardless of the type of PA. The top three PA in weighted AORs were: running (AOR: 0.51, 95 % CI: 0.50-0.52), aerobics exercise (AOR: 0.55, 95 % CI: 0.53-0.56), and weightlifting (AOR: 0.60, 95 % CI: 0.59-0.62). The dose-response relationship between PA and SCD was found. Participants who engaged in PA for 241-300 min per week (AOR: 0.61, 95 % CI: 0.59-0.62) or exercised metabolic equivalent of 801-1000 per week (AOR: 0.62, 95 % CI: 0.62-0.65) had the lowest risk of SCD.
Regardless of the specific PA types, engaging in PA is associated with a reduced risk of having SCD, and people who engage in running had the lowest risk of SCD. There was a dose-response relationship between PA and SCD, and PA-based interventions should be developed accordingly to prevent cognitive deterioration in older age.
研究表明，主观认知下降（SCD）是轻度认知障碍甚至痴呆的主要危险因素，但身体活动（PA）与SCD之间的关系仍不清楚。本研究的目的是探讨各种身体活动与SCD之间的关系。
本研究纳入了行为危险因素监测系统（BRFSS）中的216,593名成年人。我们通过参与者的自我报告来测量SCD和PA。使用无条件逻辑回归模型研究PA与SCD之间的关联。我们采用四向分解法探讨抑郁在PA与SCD之间的中介作用。采用倾向评分的最近邻匹配法和多项倾向评分法来减少混杂因素的影响。
与不活动的人相比，无论PA类型如何，身体活动者中SCD的加权调整优势比（AOR）均<1（p<0.005）。加权AOR中排名前三的PA分别是：跑步（AOR：0.51，95%CI：0.50-0.52）、有氧运动（AOR：0.55，95%CI：0.53-0.56）和举重（AOR：0.60，95%CI：0.59-0.62）。发现了PA与SCD之间的剂量反应关系。每周进行241-300分钟PA的参与者（AOR：0.61，95%CI：0.59-0.62）或每周运动代谢当量为801-1000的参与者（AOR：0.62，95%CI：0.62-0.65）患SCD的风险最低。
无论具体的PA类型如何，进行PA都与降低SCD风险相关，且跑步者患SCD的风险最低。PA与SCD之间存在剂量反应关系，应相应地开展基于PA的干预措施以预防老年人认知功能衰退。
