Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Denmark.
J Natl Cancer Inst. 2023 Jun 8;115(6):753-756. doi: 10.1093/jnci/djad039.
We investigated the impact of smoking on overall survival (OS) in testicular germ cell cancer (TC) patients receiving first-line combination chemotherapy (bleomycin-etoposide-cisplatin [BEP]). Patients who received BEP for metastatic TC were identified in the Danish Testicular Cancer database. Information on smoking status at the time of diagnosis was obtained by medical record review. OS and cause of death were compared between current smokers and never-smokers. Of 1883 eligible patients, information on smoking status was available in 1156 patients, of whom 602 were current smokers. The 10-year OS was 92% in never-smokers compared with 83% in current smokers (P < .001) (hazard ratio for death = 1.85, 95% confidence interval = 1.29 to 2.66, P = .001). A higher proportion of current smokers died of TC compared with nonsmokers (P < .01). Smoking negatively affects survival after BEP in patients with disseminated TC. Vigorous smoking cessation programs are advocated in TC patients.
我们研究了在接受一线联合化疗（博来霉素+依托泊苷+顺铂[BEP]）的睾丸生殖细胞癌（TC）患者中，吸烟对总生存（OS）的影响。在丹麦睾丸癌数据库中确定了接受 BEP 治疗转移性 TC 的患者。通过病历回顾获得诊断时的吸烟状况信息。比较了现吸烟者和从不吸烟者的 OS 和死亡原因。在 1883 名符合条件的患者中，有 1156 名患者的吸烟状况信息可用，其中 602 名是现吸烟者。从不吸烟者的 10 年 OS 为 92%，而现吸烟者为 83%（P<0.001）（死亡风险比为 1.85，95%置信区间为 1.29 至 2.66，P=0.001）。与从不吸烟者相比，更多的现吸烟者死于 TC（P<0.01）。在接受 BEP 治疗的播散性 TC 患者中，吸烟对生存有负面影响。提倡在 TC 患者中实施积极的戒烟计划。
