Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
School of Public Health, Xiamen University, Xiamen, China.
J Viral Hepat. 2023 Jun;30(6):489-496. doi: 10.1111/jvh.13820. Epub 2023 Mar 1.
In 2020, China conducted a nationwide, sero-epidemiological, cross-sectional survey of viral hepatitis. The stratified multi-stage cluster random sampling method was used to select the permanent population aged 1-69 years, followed by questionnaire survey and sample collection and detection of the serological markers of hepatitis B (HBV) and hepatitis C viruses (HCV). A total of 4747 individuals aged 1-69 years were investigated in Zhejiang Province. The positive rates of hepatitis B surface antigen and anti-HCV were 4.3% and 0%, respectively. Compared to a similar sero-epidemiological survey in 1992, the 2020 survey showed that the HBV infection rate in Zhejiang Province decreased by 56.5%. In both surveys, HBV infection rate increased with age (in 1992, χ = 185.866, p = .000; in 2020, χ = 1383.836, p = .000). Compared with 1992, the positive anti-HCV rate in those aged 1-69 years in 2020 decreased by 100.0%. This result showed that the HBV vaccine and blood screening to prevent HBV and HCV infection significantly decreased the infection rate of HBV and HCV in the younger generation of Zhejiang province. However, the rate of HBV carriers aged 30-69 years was still high, which underscores the need to strengthen the management and treatment of chronic HBV infection. Hence, Zhejiang province can eliminate the public health threat of viral hepatitis.
2020 年，中国开展了一项全国性的、血清流行病学、横断面的病毒性肝炎调查。采用分层多阶段整群随机抽样方法，选择年龄为 1-69 岁的常住人口，随后进行问卷调查和样本采集，并检测乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的血清学标志物。在浙江省共调查了 4747 名年龄为 1-69 岁的个体。乙型肝炎表面抗原和抗 HCV 的阳性率分别为 4.3%和 0%。与 1992 年的类似血清流行病学调查相比，2020 年的调查显示浙江省的 HBV 感染率下降了 56.5%。在这两项调查中，HBV 感染率随年龄增长而增加（1992 年 χ ²=185.866，p=0.000；2020 年 χ ²=1383.836，p=0.000）。与 1992 年相比，2020 年年龄在 1-69 岁的人群中抗 HCV 的阳性率下降了 100.0%。这一结果表明，HBV 疫苗和血液筛查预防 HBV 和 HCV 感染显著降低了浙江省年轻一代的 HBV 和 HCV 感染率。然而，30-69 岁的 HBV 携带者的比例仍然很高，这突显了加强慢性 HBV 感染管理和治疗的必要性。因此，浙江省可以消除病毒性肝炎对公众健康的威胁。
