Welch A B
J Biomed Mater Res. 1978 Nov;12(6):775-90. doi: 10.1002/jbm.820120602.
The effect of methyl methacrylate monomer used for polymerization of surgical bone cement on phagocytosis, blood cells, tissue cells in culture, and bacteria was investigated. A concentration of 0.5% monomer reduced the ability of macrophages in vitro to phagocytize cultures of Staphylococcus epidermidis effectively. In vivo, 0.03 ml injected into mice also reduced the capacity of peritoneal macrophages to phagocytize bacteria. Extent of cellular damage to blood cells varied with concentration of monomer used and time of contact but, in general 0.5% was sufficient to alter morphology and viability of blood cells and tissue cells in culture. Polymorphonuclear neutrophils sustained more damage than other types of blood cells. Only minor alterations were detected from cooled, polymerized cement. These studies support the concept that the monomer, as well as mechanical and thermal factors, may be responsible for some of the tissue changes seen at the site of implant of bone cement following total joint arthroplastic surgery.
研究了用于外科骨水泥聚合的甲基丙烯酸甲酯单体对吞噬作用、血细胞、培养中的组织细胞以及细菌的影响。0.5%的单体浓度有效降低了体外巨噬细胞吞噬表皮葡萄球菌培养物的能力。在体内，给小鼠注射0.03毫升也降低了腹腔巨噬细胞吞噬细菌的能力。血细胞的细胞损伤程度随所用单体浓度和接触时间而变化，但一般来说，0.5%足以改变培养中血细胞和组织细胞的形态及活力。多形核中性粒细胞比其他类型的血细胞受到的损伤更大。从冷却的聚合水泥中仅检测到轻微变化。这些研究支持了这样一种观点，即单体以及机械和热因素可能是全关节置换术后骨水泥植入部位出现的一些组织变化的原因。
