Freidhoff L R, Ehrlich-Kautzky E, Meyers D A, Marsh D G
Division of Clinical Immunology, Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Md 21239.
J Allergy Clin Immunol. 1987 Nov;80(5):646-55. doi: 10.1016/0091-6749(87)90283-1.
This study used a standardized, dialyzed, Lolium perenne (ryegrass) pollen extract and two of its well-characterized components, Lol p I (Rye I) and Lol p II (Rye II), to characterize the longitudinal variation of both IgE and IgG antibody (Ab) levels, as well as total serum IgE levels, in 20 grass-allergic subjects followed for 13 months. Ab levels declined toward a basal level just before, and increased just after, the grass-pollination season, returning to the same basal level just before the next grass-pollination season. The least complex allergen, Lol II, demonstrated the most uniform pattern of variation in both IgE and IgG Ab levels. Total serum IgE levels demonstrated the least regular pattern of variation. Grass-pollen counts were strongly correlated with symptom-medication scores for these subjects (rs = 0.87). Initial values were correlated with the rise in total IgE and IgE Ab to Lol II across the grass-pollen season. Skin test results were correlated with initial IgE Ab levels for L. perenne pollen extract and Lol II. Finally, a procedure for correcting IgE Ab levels to basal values was proposed and tested. The correction procedure, for each IgE Ab, was based on the average rise during the grass-pollination season (or average decline after the grass-pollination season) observed for all subjects with that IgE Ab.
本研究使用标准化的、经过透析的黑麦草花粉提取物及其两种特征明确的成分，即黑麦草I（Lol p I）和黑麦草II（Lol p II），对20名草花粉过敏受试者进行为期13个月的跟踪，以表征IgE和IgG抗体（Ab）水平以及总血清IgE水平的纵向变化。在草花粉授粉季节前，Ab水平降至基础水平，在授粉季节后则升高，并在下一个草花粉授粉季节前恢复到相同的基础水平。最单一的变应原Lol II在IgE和IgG Ab水平上呈现出最一致的变化模式。总血清IgE水平呈现出最不规则的变化模式。草花粉计数与这些受试者的症状-用药评分密切相关（rs = 0.87）。初始值与整个草花粉季节总IgE和针对Lol II的IgE Ab升高相关。皮肤试验结果与黑麦草花粉提取物和Lol II的初始IgE Ab水平相关。最后，提出并测试了一种将IgE Ab水平校正至基础值的方法。针对每种IgE Ab的校正方法基于所有具有该IgE Ab的受试者在草花粉授粉季节期间的平均升高（或草花粉授粉季节后的平均下降）。
