英夫利昔单抗对四氯化碳诱导的大鼠脾脏毒性的影响。
Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats.
作者信息
Bahcecı I, Tumkaya L, Mercantepe T, Yılmaz H, Ibık Y E, Duran O F, Arslan N
机构信息
Department of Medical Microbiology, Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
出版信息
Eur Rev Med Pharmacol Sci. 2023 Feb;27(3):1140-1146. doi: 10.26355/eurrev_202302_31220.
OBJECTIVE
Carbon tetrachloride (CCl4) is a non-polar molecule used in industry in grain curing, insect-killing and especially in the production of chlorofluorocarbons. It is estimated that an average of 70,000 industry workers in Europe are exposed to this toxic compound.
MATERIALS AND METHODS
Twenty-four male Sprague-Dawley rats were randomly allocated into four groups: control group (saline only, Group I), infliximab (INF) group (Group II), CCl4 group (Group III) and CCl4+INF group (Group IV).
RESULTS
While there was an increase in the numerical density of CD3, CD68, and CD200R positive T lymphocytes and macrophages in the CCl4 administration group (p=0.000), this was not the case in the CCl4+INF administration group (p=0.000).
CONCLUSIONS
TNF-α inhibitors have a protective effect against CCl4-induced spleen toxicity/inflammation as seen by the reduction in CD3, CD68, CD200R positive T lymphocytes and macrophages.
目的
四氯化碳（CCl4）是一种非极性分子，用于谷物熏蒸、杀虫等工业领域，尤其是在氯氟烃的生产中。据估计，欧洲平均有70000名产业工人接触这种有毒化合物。
材料与方法
将24只雄性Sprague-Dawley大鼠随机分为四组：对照组（仅生理盐水，I组）、英夫利昔单抗（INF）组（II组）、CCl4组（III组）和CCl4+INF组（IV组）。
结果
CCl4给药组CD3、CD68和CD200R阳性T淋巴细胞及巨噬细胞的数值密度增加（p=0.000），而CCl4+INF给药组则不然（p=0.000）。
结论
肿瘤坏死因子-α抑制剂对CCl4诱导的脾脏毒性/炎症具有保护作用，表现为CD3、CD68、CD200R阳性T淋巴细胞和巨噬细胞数量减少。
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