Magne Nicolas, Milhade Nicolas, Sargos Paul, Bouleftour Wafa
Department of Radiation Oncology, Institut Bergonié, 229 cours de l'Argonne, 33000, Bordeaux, France.
Cellular and Molecular Radiobiology Laboratory, Lyon-Sud Medical School, Unité Mixte de Recherche CNRS5822/IP2I, University of Lyon, Lyon, France.
Curr Oncol Rep. 2023 Apr;25(4):251-256. doi: 10.1007/s11912-023-01379-4. Epub 2023 Feb 18.
This study aims to gather the current state of the literature about therapeutic approaches and management of oligometastatic renal cell carcinoma.
Two recent stereotactic body radiotherapy (SBRT) studies gained attention and offered a promising outcome alone or in association with antineoplastic drugs especially in oligometastatic renal cell carcinoma. If one can consider evidence-based medicine as the sole therapeutic option, many unresolved questions are still pending. Thus, therapeutic approaches in oligometastatic renal cell carcinoma are still working. Further phase III clinical trials are urgently needed to validate the last 2 phase II involving SBRT and improve knowledge for defining the right care to the right patient at the right time. In addition, a discussion in a disciplinary consultation meeting remains essential to validate the arrangement between systemic treatments and focal treatments that will best benefit the patient.
本研究旨在收集有关寡转移性肾细胞癌治疗方法和管理的当前文献状态。
最近的两项立体定向体部放疗(SBRT)研究受到关注,单独或与抗肿瘤药物联合使用时取得了有前景的结果,尤其是在寡转移性肾细胞癌中。如果将循证医学视为唯一的治疗选择,仍有许多未解决的问题悬而未决。因此,寡转移性肾细胞癌的治疗方法仍在不断探索。迫切需要进一步的III期临床试验来验证最近涉及SBRT的2项II期试验,并提高在正确时间为正确患者确定合适治疗方案的认知。此外,学科咨询会议中的讨论对于验证全身治疗和局部治疗之间最有利于患者的安排仍然至关重要。