轴突和突触前 FMRP：定位、信号及功能意义。
Axonal and presynaptic FMRP: Localization, signal, and functional implications.
机构信息
Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, China.
Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
出版信息
Hear Res. 2023 Mar 15;430:108720. doi: 10.1016/j.heares.2023.108720. Epub 2023 Feb 11.
Abstract
Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.
摘要
脆性 X 智力低下蛋白（FMRP）结合了一组特定的信使 RNA 和蛋白质，以指导神经回路的组装并调节突触可塑性。FMRP 的缺失是脆性 X 综合征的原因，这是一种神经精神疾病，其特征是听觉处理问题和社交困难。FMRP 在突触的四个隔室（突触前和突触后神经元、星形胶质细胞和细胞外基质）中的突触形成、成熟和可塑性中的作用具有特异性。这篇综述总结了在理解 FMRP 在轴突和突触前末梢中的定位、信号和功能作用方面的进展。
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