Young A R, Gibbs N K, Magnus I A
Department of Photobiology, United Medical School of Guy's, London.
J Invest Dermatol. 1987 Dec;89(6):611-7. doi: 10.1111/1523-1747.ep12461386.
Sunscreen preparations containing 5-methoxypsoralen at 25 micrograms/ml and 50 micrograms/ml, and the appropriate vehicle only, sunscreen only, and 5-methoxypsoralen only controls, were assessed for tumorigenic potential in hairless albino mice exposed to solar simulated radiation for a period of 44-46 weeks. Some animals were observed for a 15 week post-irradiation period. A wide range of statistical analyses has shown that, during the course of irradiation, the inclusion of sunscreens eliminates the enhancement of phototumorigenesis and malignancy that is normally observed with 5-methoxypsoralen. There was, however, some indication of increased risk at the end of the postirradiation follow-up period. Possible reasons for the protective effect of the sunscreens and the relevance of these data to the assessment of human risk are discussed.
对含有浓度为25微克/毫升和50微克/毫升的5-甲氧基补骨脂素的防晒制剂、仅含相应赋形剂的对照组、仅含防晒剂的对照组以及仅含5-甲氧基补骨脂素的对照组，在暴露于模拟太阳辐射44 - 46周的无毛白化小鼠中评估其致瘤潜力。部分动物在照射后观察15周。大量统计分析表明，在照射过程中，添加防晒剂可消除通常在使用5-甲氧基补骨脂素时观察到的光致瘤作用和恶性程度增强。然而，在照射后随访期结束时有一些风险增加的迹象。讨论了防晒剂产生保护作用的可能原因以及这些数据与人类风险评估的相关性。
