Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Cancer Drug Targets. 2023;23(7):524-533. doi: 10.2174/1568009623666230210140212.
Nowadays, nano-platforms designed for drug delivery systems (DDSs) such as polymers, liposomes, and micelles have been demonstrated to be clinically efficient. The sustained drug release is one of the advantages of DDSs, especially polymer-based nanoparticles. The formulation could enhance the drug's durability, in which the biodegradable polymers are the most interesting building blocks of DDSs. Nano-carriers could circumvent many issues by localized drug delivery and release via certain internalization routes such as intracellular endocytosis paths and increasing biocompatibility. Polymeric nanoparticles and their nanocomposite are one of the most important classes of materials that can be used for the assembly of nanocarriers that can form complex, conjugated and encapsulated forms. The site-specific drug delivery may arise from the ability of nanocarriers to pass through the biological barrier, their specific interactions with receptors, and passive targeting. The better circulation, uptake, and stability along with targeting attributes lead to lesser side effects and damage to normal cells. Hence, in this review, the most recent achievements on polycaprolactone-based or -modified nanoparticles in drug delivery systems (DDSs) for 5-fluorouracil (5-FU) are presented.
如今，用于药物递送系统（DDS）的纳米平台，如聚合物、脂质体和胶束，已被证明具有临床疗效。DDS 的优点之一是药物的持续释放，特别是基于聚合物的纳米粒子。该制剂可以提高药物的耐久性，其中可生物降解的聚合物是 DDS 最有趣的构建块。纳米载体可以通过特定的内化途径（如细胞内内吞途径）局部递药和释放来规避许多问题，并提高生物相容性。聚合物纳米粒子及其纳米复合材料是最重要的一类材料之一，可用于组装纳米载体，形成复杂、共轭和封装的形式。药物的靶向递药可能源于纳米载体穿透生物屏障的能力、与受体的特异性相互作用以及被动靶向。更好的循环、摄取和稳定性以及靶向特性导致副作用和对正常细胞的损伤更小。因此，在本综述中，介绍了基于聚己内酯或改性聚己内酯的纳米粒子在 5-氟尿嘧啶（5-FU）药物递送系统（DDS）中的最新研究进展。
