Ni Hui, Sun Xiaoye, Cong Hui
Department of Blood Transfusion, Affiliated Hospital of Nantong University, Nantong, China.
Lab Med. 2023 Sep 5;54(5):507-511. doi: 10.1093/labmed/lmac160.
The presence of red blood cell (RBC) irregular antibodies can severely jeopardize mother and child and bring trouble to the treatment of anemia. The aim of this study was to analyze the specificity of RBC irregular antibody in inpatients.
An analysis was performed on samples from patients with RBC irregular antibodies. Antibody screening positive samples were analyzed.
Among the 778 cases of irregular antibody positive samples, 214 were from males and 564 from females. History of blood transfusion accounted for 13.1% of the total. Of the women, 96.8% had a pregnancy. A total of 131 antibodies were identified. The antibodies included 68 Rh systematic antibodies, 6 MNS systematic antibodies, 6 Lewis systematic antibodies, 2 Kidd systematic antibodies, 10 autoantibodies, and 39 antibodies of uncertain specificity.
Patients with blood transfusion or pregnancy history are prone to produce RBC irregular antibodies.
红细胞（RBC）不规则抗体的存在会严重危及母婴，并给贫血治疗带来麻烦。本研究旨在分析住院患者中RBC不规则抗体的特异性。
对红细胞不规则抗体患者的样本进行分析。对抗体筛查呈阳性的样本进行分析。
在778例不规则抗体阳性样本中，男性214例，女性564例。输血史占总数的13.1%。在女性中，96.8%有过妊娠史。共鉴定出131种抗体。这些抗体包括68种Rh系统抗体、6种MNS系统抗体、6种Lewis系统抗体、2种Kidd系统抗体、10种自身抗体和39种特异性不确定的抗体。
有输血或妊娠史的患者容易产生红细胞不规则抗体。
