Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, China.
Department of Pharmacy, Ganzhou Fifth People's Hospital, Ganzhou, China.
Dig Dis. 2023;41(4):622-631. doi: 10.1159/000529815. Epub 2023 Feb 22.
The assessment of liver fibrosis has been a critical component in the clinical management of liver diseases. We performed a meta-analysis to evaluate serum Golgi protein 73 (GP73) in the diagnosis of liver fibrosis.
A literature search was performed in eight databases until July 13, 2022. We strictly searched studies according to inclusion and exclusion criteria, extracted data, and then assessed quality. We pooled the sensitivity, specificity, and other diagnostic estimates of serum GP73 to assess liver fibrosis. Moreover, publication bias, threshold analysis, sensitivity analysis, meta-regression, subgroup analysis, and post-test probability were evaluated.
Our research integrated 16 articles including 3,676 patients. Potential publication bias and threshold effect were not found. The pooled sensitivity, specificity, and area under the curve of the summary receiver operating characteristic curve were 0.63, 0.79, and 0.818 for significant fibrosis; 0.77, 0.76, and 0.852 for advanced fibrosis; and 0.80, 0.76, and 0.894 for cirrhosis, respectively. The aetiology was one of the important sources of heterogeneity.
Serum GP73 was a feasible diagnostic marker for liver fibrosis, which is of great significance for the clinical management of liver diseases.
肝纤维化的评估一直是肝脏疾病临床管理的重要组成部分。我们进行了一项荟萃分析，以评估血清高尔基糖蛋白 73（GP73）在诊断肝纤维化中的作用。
我们在八个数据库中进行了文献检索，检索截至 2022 年 7 月 13 日。我们严格按照纳入和排除标准进行研究搜索，提取数据，然后评估质量。我们汇总了血清 GP73 诊断肝纤维化的敏感性、特异性和其他诊断评估指标。此外，还评估了发表偏倚、阈值分析、敏感性分析、meta 回归、亚组分析和后验概率。
我们的研究整合了 16 篇文章，共纳入 3676 名患者。未发现潜在的发表偏倚和阈值效应。汇总的显著纤维化、进展性纤维化和肝硬化的敏感性、特异性和综合受试者工作特征曲线下面积分别为 0.63、0.79 和 0.818、0.77、0.76 和 0.852、0.80、0.76 和 0.894。病因是异质性的重要来源之一。
血清 GP73 是肝纤维化的一种可行的诊断标志物，对肝脏疾病的临床管理具有重要意义。
