Goda S, Ishimoto S, Goto I, Kuroiwa Y, Koike K, Koike M, Nakagawa M, Reichmann H, DiMauro S
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1348-52. doi: 10.1136/jnnp.50.10.1348.
The alpha-keto acid dehydrogenase complex and its component enzymes, lactate dehydrogenase, pyruvate carboxylase, cytochrome c oxidase, succinate-cytochrome c reductase, NADH-cytochrome c reductase, and the concentration of cytochromes and enzymes of beta-oxidation in muscle from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes were studied and no specific defect was found. These results raise the possibility that the mitochondrial changes in the patient may be secondary.
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