Carter D A, Lisney S J
Department of Physiology, Medical School, Bristol, U.K.
J Neurol Sci. 1987 Sep;80(2-3):163-71. doi: 10.1016/0022-510x(87)90152-3.
Counts have been made of the numbers of unmyelinated and myelinated axons in the proximal and distal stumps of regenerated rat saphenous nerves and from equivalent sites in normal nerves. In the proximal part of normal nerves there were averages of 1,045 myelinated axons and 4,160 unmyelinated ones. Regenerated nerves contained the same number of myelinated axons in their proximal stumps but there was a 40% reduction in the unmyelinated axon count. In the distal stumps of these nerves the myelinated axon count had increased by an average of 620; this comes about because some regenerated myelinated axons support more than one process in the distal stump. In contrast, the number of unmyelinated axons was reduced further, from a mean of 2,476 in the proximal stump to one of 2,219. The sizes of Schwann cell units in the normal and regenerated nerves were also noted. Schwann cell units in the proximal and distal stumps of the regenerated nerves were smaller than those in the normal ones. These changes associated with unmyelinated axons in regenerated nerves are likely to contribute to the sensory, vasomotor and sudomotor abnormalities that sometimes occur after peripheral nerve injury and regeneration.
已对再生大鼠隐神经近端和远端残端以及正常神经相同部位的无髓鞘和有髓鞘轴突数量进行了计数。在正常神经的近端，平均有1045条有髓鞘轴突和4160条无髓鞘轴突。再生神经的近端残端含有相同数量的有髓鞘轴突，但无髓鞘轴突数量减少了40%。在这些神经的远端残端，有髓鞘轴突数量平均增加了620条；这是因为一些再生的有髓鞘轴突在远端残端支持不止一个突起。相比之下，无髓鞘轴突数量进一步减少，从近端残端的平均2476条减少到2219条。还记录了正常神经和再生神经中施万细胞单位的大小。再生神经近端和远端残端的施万细胞单位比正常神经中的小。再生神经中与无髓鞘轴突相关的这些变化可能导致周围神经损伤和再生后有时出现的感觉、血管舒缩和发汗运动异常。
