Department of CNS drug innovation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Prog Mol Biol Transl Sci. 2023;196:99-111. doi: 10.1016/bs.pmbts.2022.09.005. Epub 2022 Oct 22.
This chapter describes the physiological significance of dopamine receptor endocytosis and the consequence of the receptor signaling. Endocytosis of dopamine receptors is regulated by many components such as clathrin, β-arrestin, caveolin, and Rab family proteins. The dopamine receptors escape from lysosomal digestion, and their recycling occurs rapidly, reinforcing the dopaminergic signal transduction. In addition, the pathological impact of the receptors interacting with specific proteins has been the focus of much attention. Based on this background, this chapter provides an in-depth understanding of the mechanisms of molecules interacting with dopamine receptors and discusses the potential pharmacotherapeutic targets for α-synucleinopathies and neuropsychiatric disorders.
本章描述了多巴胺受体内吞作用的生理意义及其受体信号转导的后果。多巴胺受体的内吞作用受到许多成分的调节，如网格蛋白、β-arrestin、小窝蛋白和 Rab 家族蛋白。多巴胺受体逃避溶酶体消化，其循环快速发生，从而增强多巴胺能信号转导。此外，受体与特定蛋白质相互作用的病理影响一直是关注的焦点。基于这一背景，本章深入了解了与多巴胺受体相互作用的分子机制，并讨论了用于 α-突触核蛋白病和神经精神疾病的潜在药物治疗靶点。
