Cognitive Function Deterioration After Cardiopulmonary Bypass: Can Intraoperative Optimal Cerebral Regional Tissue Oxygen Saturation Predict Postoperative Cognitive Function?

OBJECTIVE

Cognitive impairment is a common neurologic complication after cardiac surgery with cardiopulmonary bypass (CPB). This study evaluated postoperative cognitive function to determine predictors of cognitive dysfunction, including intraoperative cerebral regional tissue oxygen saturation (rSO).

DESIGN

A prospective observational cohort study.

SETTING

At a single academic tertiary-care center.

PARTICIPANTS

A total of 60 adults undergoing cardiac surgery with CPB from January to August 2021.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

All patients underwent Mini-Mental State Examination (MMSE) and quantified electroencephalography (qEEG) 1 day before cardiac surgery, 7 days postoperatively (POD7), and POD60. Intraoperative cerebral rSO was monitored continuously. For MMSE, no significant decrease in MMSE score was found on POD7 versus preoperatively (p = 0.09), but POD60 scores showed significant improvement compared with both preoperative (p = 0.02) and POD7 scores (p < 0.001). On qEEG, relative theta power on POD7 was increased versus preoperatively (p < 0.001), but it was decreased on POD60 (POD7 versus POD60, p < 0.001), and was close to preoperative data (p > 0.99). Baseline rSO was an independent factor for postoperative MMSE. Both baseline and mean rSO showed a significant influence in postoperative relative theta activity, whereas mean rSO was the only predictor for the theta-gamma ratio (p = 0.04).

CONCLUSIONS

The MMSE in patients undergoing CPB declined at POD7 and recovered by POD60. Lower baseline rSO indicated a higher potential for MMSE decline at POD60. Inferior intraoperative mean rSO was related to higher postoperative relative theta activity and theta-gamma ratio, implying subclinical or further cognitive impairment.