Lichtor T, Davis H R, Johns L, Vesselinovitch D, Wissler R W, Mullan S
Section of Neurological Surgery, University of Chicago Medical Center, Illinois.
J Neurosurg. 1987 Dec;67(6):906-14. doi: 10.3171/jns.1987.67.6.0906.
Morphometric and chemical changes in the arterial wall were studied after 12 months of diet-induced atherosclerosis in rhesus monkeys treated with either bilateral surgical thoracic sympathectomy or propranolol. There was a marked reduction in the progression of atherosclerosis in the carotid arteries and a moderate reduction in the disease found in the thoracic aorta of monkeys treated initially with a sympathectomy, in comparison to control monkeys fed an atherogenic diet alone. Propranolol at a dose of 40 mg/12 hrs also seemed to reduce the progression of atherosclerosis in the carotid arteries and thoracic aorta, although the differences were less dramatic. There were minimal differences in the extent of atherosclerosis in the abdominal aorta or femoral arteries of animals in either treatment group as compared with the control group. Similarly, the chemical composition of these same major vessels showed no significant differences. Therefore, in the face of severe atherogenic stimuli, chemical or surgical sympathectomy may be useful in controlling atherosclerosis in specific arterial beds.
在用双侧手术性胸交感神经切除术或普萘洛尔治疗的恒河猴中，研究了饮食诱导动脉粥样硬化12个月后动脉壁的形态学和化学变化。与仅喂食致动脉粥样硬化饮食的对照猴相比，最初接受交感神经切除术治疗的猴，其颈动脉粥样硬化进展明显降低，胸主动脉疾病有中度减轻。剂量为40mg/12小时的普萘洛尔似乎也能降低颈动脉和胸主动脉粥样硬化的进展，尽管差异不那么显著。与对照组相比，任一治疗组动物腹主动脉或股动脉的动脉粥样硬化程度差异最小。同样，这些相同主要血管的化学成分也没有显著差异。因此，面对严重的致动脉粥样硬化刺激，化学或手术性交感神经切除术可能有助于控制特定动脉床的动脉粥样硬化。
