Brown W D, Setzer J V, Dick R B, Phipps F C, Lowry L K
Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
J Occup Med. 1987 Nov;29(11):877-83.
The dynamics of inhaled solvents have not been studied extensively for exposure conditions involving combinations of chemical agents. An ongoing laboratory study examining psychomotor performance effects on human volunteers exposed to spray paint agents offered an opportunity to gather data on the body burden profiles produced by the inhalation of two solvents alone and in combination. Breath and blood samples were collected from 70 male and female subjects who were randomly assigned to four treatment conditions: chemical placebo, 250 ppm acetone, 200 ppm methyl ethyl ketone, or 125 ppm acetone/100 ppm methyl ethyl ketone. The exposures lasted for four hours. No interaction between the two solvents affecting uptake or elimination was noted. There were no significant differences between the uptake and elimination in males and females. The results are discussed in relation to physiological simulation modeling of the exposure.
对于涉及化学制剂组合的暴露条件，吸入性溶剂的动力学尚未得到广泛研究。一项正在进行的实验室研究，旨在考察喷漆制剂对人类志愿者精神运动表现的影响，该研究提供了一个机会，来收集关于单独吸入两种溶剂以及同时吸入这两种溶剂所产生的体内负荷情况的数据。从70名男性和女性受试者中采集了呼吸和血液样本，这些受试者被随机分配到四种处理条件下：化学安慰剂、250 ppm丙酮、200 ppm甲乙酮，或125 ppm丙酮/100 ppm甲乙酮。暴露持续4小时。未观察到两种溶剂之间在影响吸收或消除方面存在相互作用。男性和女性在吸收和消除方面没有显著差异。结合暴露的生理模拟模型对结果进行了讨论。
