Xiu Chao, Ni Donghe, Zhao Jincui, Yu Yang
Medical Imaging Center, Affiliated Hospital of Beihua University, Jilin City, China.
Nuclear Magnetic Resonance Department, Integrated Traditional Chinese and Western Medicine Hospital of Jilin Province, Jilin City, China.
Front Neurol. 2023 Feb 6;14:1084911. doi: 10.3389/fneur.2023.1084911. eCollection 2023.
Intracranial cavernous angioma (ICA) is a cerebrovascular malformation. It causes local neurological dysfunction, epilepsy, intracranial hemorrhage (ICH) and other symptoms, seriously affecting the safety of patients. This study analyzed middle-aged and elderly patients with ICA in our hospital, summarized the characteristics of the disease and investigated the related factors of ICH.
We conducted a retrospective analysis of 120 middle-aged and elderly patients who were diagnosed with ICA by magnetic resonance imaging in our hospital from March 2018 to September 2021. The cases were assigned to either a bleeding group (i.e., the experimental group) or a non-bleeding group (i.e., the control group). The characteristics of the disease, including gender, age, number of lesions, form and symptoms of onset, distribution of lesions, blood supply vessels in the lesion area, size of the lesion and presence of bleeding, were summarized and analyzed. The relationship between these factors and ICH was investigated, and the data were analyzed using SPSS 25.0 software.
There were 56 cases in the experimental group and 64 cases in the control group. A univariate analysis showed that gender, age, body mass index, blood lipids, number of lesions, course of the disease, onset of symptoms and disease characteristics were not associated with ICH in the middle-aged and elderly patients with ICA ( > 0.05). The maximum diameter, volume, location and blood supply area of the lesions were related to ICA complicated with ICH ( < 0.05). A multivariate unconditional logistic regression analysis revealed that the maximum diameter, volume, location and blood supply area of the lesions were independent risk factors for ICH in the middle-aged and elderly patients with ICA. The odds ratio (OR) of the maximum diameter of the lesion was 4.410, the OR of the lesion volume was 7.316, the OR of the lesion site was 7.470, and the OR of the blood supply area was 1.6588.
Intracranial cavernous angioma lesions in middle-aged and elderly patients occur mainly in the supratentorial area, with a small part located in the infratentorial area. The main form of the disease is chronic recurrence. The occurrence of bleeding is related to the size, location and blood supply of the lesion.
颅内海绵状血管瘤（ICA）是一种脑血管畸形。它会导致局部神经功能障碍、癫痫、颅内出血（ICH）等症状，严重影响患者的安全。本研究分析了我院中老年ICA患者的情况，总结了该疾病的特点并探究了ICH的相关因素。
我们对2018年3月至2021年9月在我院通过磁共振成像诊断为ICA的120例中老年患者进行了回顾性分析。将病例分为出血组（即实验组）和非出血组（即对照组）。总结并分析了疾病的特征，包括性别、年龄、病灶数量、发病形式和症状、病灶分布、病灶区域的供血血管、病灶大小及出血情况。研究了这些因素与ICH之间的关系，并使用SPSS 25.0软件对数据进行分析。
实验组有56例，对照组有64例。单因素分析显示，性别、年龄、体重指数、血脂、病灶数量、病程、症状发作及疾病特征与中老年ICA患者的ICH无关（P>0.05）。病灶的最大直径、体积、位置及供血区域与ICA合并ICH有关（P<0.05）。多因素非条件logistic回归分析显示，病灶的最大直径、体积、位置及供血区域是中老年ICA患者ICH的独立危险因素。病灶最大直径的比值比（OR）为4.410，病灶体积的OR为7.316，病灶部位的OR为7.470，供血区域的OR为1.6588。
中老年患者颅内海绵状血管瘤病灶主要发生在幕上区域，一小部分位于幕下区域。该疾病的主要形式是慢性复发。出血的发生与病灶的大小、位置及供血有关。
