Chen Eric L, Siu Jason, Bastawrous Sarah, Truong Camtu D, Wu Lei
Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA.
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle WA, 98195, USA.
Radiol Case Rep. 2023 Feb 7;18(4):1536-1543. doi: 10.1016/j.radcr.2023.01.056. eCollection 2023 Apr.
Renal oncocytomas are commonly reported in association with Birt-Hogg-Dube (BHS) syndrome, while BHD-associated oncocytomas of the parotid gland are rare. To date, there have been only 11 cases of BHD-associated parotid gland oncocytoma, without a reported case of malignant transformation. We present the first reported case of oncocytic carcinoma of the parotid gland associated with BHD, with radiologic and histologic correlation. This case establishes that BHD-associated parotid oncocytic lesions, previously identified only as benign oncocytomas in the literature to date, can undergo malignant transformation, and should potentially be regarded with a higher index of suspicion and lower threshold for aggressive management.
肾嗜酸细胞瘤通常与Birt-Hogg-Dube（BHS）综合征相关，而与BHD相关的腮腺嗜酸细胞瘤则较为罕见。迄今为止，仅有11例与BHD相关的腮腺嗜酸细胞瘤病例，尚无恶变病例的报道。我们报告首例与BHD相关的腮腺嗜酸细胞癌病例，并进行影像学和组织学对照分析。该病例证实，此前文献中仅认定为良性嗜酸细胞瘤的BHD相关腮腺嗜酸细胞性病变可发生恶变，因此对其应提高怀疑指数并降低积极治疗的阈值。
