Clinical & Health Sciences, University of South Australia, Adelaide, Australia.
Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia.
J Sleep Res. 2023 Aug;32(4):e13855. doi: 10.1111/jsr.13855. Epub 2023 Feb 23.
Micronutrients, particularly amino acids, are thought to play an important role in sleep regulation and maintenance. While tryptophan is a known predictor of sleep, less is known about branched-chain amino acids (BCAAs), which compete with tryptophan for transport across the blood-brain barrier. The aim of this study was to determine the association between BCAAs and actigraphy-derived sleep duration, timing and efficiency, and self-reported trouble sleeping. This study examined data on children and adults collected as part of the Child Health CheckPoint study. Linear mixed models, adjusted for geographic clustering, were used to determine the association between BCAAs and sleep characteristics. Complete-case analysis was conducted for 741 children aged 11-12 years old (51% females) and 941parents (87% mothers). While BCAAs were significantly associated with children's sleep duration, timing and self-reported trouble sleeping, no associations were observed in adults, in fully adjusted models. In children, higher levels of BCAAs are associated with shorter sleep duration, delayed sleep timing, and more frequent reports of trouble sleeping.
微量营养素，特别是氨基酸，被认为在睡眠调节和维持中发挥重要作用。虽然色氨酸是睡眠的已知预测因子，但对于支链氨基酸（BCAAs）的了解较少，BCAAs 与色氨酸竞争通过血脑屏障的转运。本研究旨在确定 BCAAs 与活动记录仪衍生的睡眠持续时间、时间和效率以及自我报告的睡眠困难之间的关联。本研究检查了作为儿童健康 CheckPoint 研究一部分收集的儿童和成人数据。线性混合模型，调整了地理聚类，用于确定 BCAAs 与睡眠特征之间的关联。对 741 名 11-12 岁的儿童（51%为女性）和 941 名家长（87%为母亲）进行了完整病例分析。虽然 BCAAs 与儿童的睡眠持续时间、时间和自我报告的睡眠困难显著相关，但在完全调整的模型中，成年人没有观察到关联。在儿童中，较高水平的 BCAAs 与较短的睡眠持续时间、延迟的睡眠时间和更频繁的睡眠困难报告有关。
