H Usmani, S Malik, A Arya, Pk Mahto, R Kant, R Dua, D Sindhwani, Aa Mirza, Panda P K
Department of Biochemistry, AIIMS, Rishikesh, India.
Department of Pulmonary Medicine, AIIMS, Rishikesh, India.
Recent Adv Antiinfect Drug Discov. 2023 Feb 22. doi: 10.2174/2772434418666230222140805.
SARS-CoV-2 infection that led to the COVID-19 pandemic has changed human health and the economy globally. SARS CoV-2 is a type of Coronaviruses that has caused pneumonia and its complications with many deaths over the past two years. The use of hydroxychloroquine and chloroquine, accepted as generally safe for patients with autoimmune diseases or malaria, was attempted in many trials for COVID-19 treatment. Nigella sativa (NS) (black caraway, also known as black cumin, nigella or Kalonji) is an annual flowering plant of the Ranunculaceae family, chemically composed of the main constituent natural Thymoquinone (TQ) (30%- 48%) in forms of thymohydroquinone, dithymoquinone (Nigellone) is a native to wider regions, including parts of eastern Europe, west Asia, North of Africa and east of Myanmar. In this review, we explored the Randomized Controlled Trial, Controlled Trial, and Systematic review studies that support Nigella sativa Thymoquinone-targeted SARS-CoV-2 targeting. Therefore, A literature search was performed for publications published on the electronic databases (PubMed, Embase, Scopus, CNKI, and Google Scholar) for Nigella sativa, black seeds, Kalonji, coronavirus, SARS-CoV -2 and COVID-19. This review aimed to find relevant evidence of Nigella sativa preferences as a natural feasible remedy with no side effects in COVID-19. Studies reported the benefits of NS as beneficial, another appropriate remedy for patients with COVID-19. However, all studies have shown limitations, such as limiting clinical symptom outcomes due to regulations imposed by isolation policies and lack of adequate funding. Therefore, the evidence suggests that the chemical contents of NS are a safe and possible treatment for COVID-19 patients that helps to improve COVID-19 infection in patients with no side effects.
Nigella sativa seeds were one of the well-documented herbal products. Three reviewed randomized controlled trials reported that NS reduced covid-19 risk and could improve immune function. It was also helpful in upper respiratory infections such as asthma and bronchitis, with one RCT showing that honey and NS significantly improved symptoms, viral clearance, and mortality of COVID-19 patients. This review concludes that NS has a positive barrier effect on people at risk of acquiring a COVID-19 infection.
导致新冠疫情的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染改变了全球人类健康和经济状况。SARS-CoV-2是一种冠状病毒，在过去两年中引发了肺炎及其并发症，并导致许多人死亡。羟氯喹和氯喹在自身免疫性疾病或疟疾患者中通常被认为是安全的，许多治疗新冠的试验都尝试使用了它们。黑种草（NS）（黑香菜，也称为黑孜然、黑种草籽或卡隆吉）是毛茛科一年生开花植物，其化学成分主要为天然百里醌（TQ）（30%-48%），还包括百里氢醌、二百里醌（黑种草酮）等形式，原产于更广泛的地区，包括东欧部分地区、西亚、北非和缅甸东部。在本综述中，我们探讨了支持黑种草百里醌靶向SARS-CoV-2的随机对照试验、对照试验和系统评价研究。因此，我们在电子数据库（PubMed、Embase、Scopus、中国知网和谷歌学术）中搜索了关于黑种草、黑籽、卡隆吉、冠状病毒、SARS-CoV-2和新冠的已发表文献。本综述旨在寻找黑种草作为新冠天然可行且无副作用疗法的相关证据。研究报告称黑种草对新冠患者有益，是另一种合适的疗法。然而，所有研究都显示出局限性，例如由于隔离政策的规定限制了临床症状结果，以及缺乏足够的资金。因此，证据表明黑种草的化学成分对新冠患者是一种安全且可能的治疗方法，有助于改善患者的新冠感染且无副作用。
黑种草籽是记载充分的草药产品之一。三项综述的随机对照试验报告称，黑种草降低了新冠风险，并可改善免疫功能。它对哮喘和支气管炎等上呼吸道感染也有帮助，一项随机对照试验表明，蜂蜜和黑种草显著改善了新冠患者的症状、病毒清除率和死亡率。本综述得出结论，黑种草对有感染新冠风险的人有积极的防护作用。
