Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
mSystems. 2023 Feb 23;8(1):e0119922. doi: 10.1128/msystems.01199-22. Epub 2023 Jan 19.
The spread of multidrug-resistant zoonotic pathogens, such as Salmonella, within livestock is of concern for food safety. The spread of Salmonella on the farm is escalated by superspreaders, which shed the pathogen at high numbers with their feces. However, there are currently no biomarkers to identify potential superspreaders. Kempf and coworkers determined that a potent early inflammatory response to Salmonella infection and changes in the microbiota composition are associated with the superspreader phenotype in pigs (F. Kempf, G. Cordoni, A.M. Chaussé, R. Drumo, et al., , in press, https://doi.org/10.1128/msystems.00852-22). Since these biomarkers only develop during Salmonella infection, additional work is needed to predict animals that have the potential to become superspreaders.
多药耐药性人畜共患病原体（如沙门氏菌）在牲畜中的传播引起了人们对食品安全的关注。超级传播者会加剧沙门氏菌在农场中的传播，因为它们的粪便中会大量排出病原体。然而，目前还没有生物标志物来识别潜在的超级传播者。Kempf 及其同事发现，对沙门氏菌感染的强烈早期炎症反应和微生物组组成的变化与猪的超级传播者表型有关（F. Kempf, G. Cordoni, A.M. Chaussé, R. Drumo, 等，待发表，https://doi.org/10.1128/msystems.00852-22）。由于这些生物标志物仅在沙门氏菌感染期间才会出现，因此需要进一步研究来预测有潜力成为超级传播者的动物。
