神经肽Y对去神经和未去神经大鼠尾动脉的作用。
Actions of neuropeptide Y on innervated and denervated rat tail arteries.
作者信息
Neild T O
机构信息
Department of Physiology, Monash University, Clayton, Victoria, Australia.
出版信息
J Physiol. 1987 May;386:19-30. doi: 10.1113/jphysiol.1987.sp016519.
Abstract
- Neuropeptide Y caused a dose-dependent contraction and depolarization of the smooth muscle of the rat tail artery. 2. 30 nM-neuropeptide Y increased the contraction caused by either nerve-released noradrenaline or smooth muscle action potentials. 3. 30 nM-neuropeptide Y did not change the amplitude or rate of rise of the smooth muscle action potential. It did not change the amplitude of small excitatory junction potentials, suggesting that it did not affect neurotransmitter release. 4. 30 nM-neuropeptide Y increased the contraction caused by exogenous noradrenaline, 5-hydroxytryptamine and K in concentrations that gave submaximal contractions. It did not affect the response to higher concentrations that gave maximal or near-maximal contractions.
摘要
- 神经肽Y引起大鼠尾动脉平滑肌剂量依赖性收缩和去极化。2. 30 nM神经肽Y增强了神经释放的去甲肾上腺素或平滑肌动作电位所引起的收缩。3. 30 nM神经肽Y未改变平滑肌动作电位的幅度或上升速率。它也未改变小兴奋性突触后电位的幅度，这表明它不影响神经递质释放。4. 30 nM神经肽Y增强了外源性去甲肾上腺素、5-羟色胺和钾在产生次最大收缩浓度时所引起的收缩。它不影响对产生最大或接近最大收缩的更高浓度的反应。
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