Zhu Jie, Li Shuyue, Zhao Ying, Xiong Yu
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
Front Pharmacol. 2023 Feb 2;14:1072578. doi: 10.3389/fphar.2023.1072578. eCollection 2023.
Twin pregnancy was associated with significantly higher rates of adverse neonatal and perinatal outcomes. One of the underlying causes is that twins are prone to preterm birth. Antenatal corticosteroids are widely used for reducing the incidence of neonatal respiratory distress syndrome initially and other neonatal mortality and morbidities subsequently. As it is widely used as a prophylactic treatment for potential premature births, there remain controversies of issues relating to twin gestations, including window for opportunity, timing of use, repeat course, optimal administration-to-delivery intervals, dosage, and type of corticosteroid. Thus, we present a thorough review of antenatal corticosteroids usage in twin gestation, emphasizing the aforementioned issues and attempting to offer direction for future investigation and clinical practice.
双胎妊娠与显著更高的不良新生儿和围产期结局发生率相关。其中一个潜在原因是双胞胎容易早产。产前使用皮质类固醇最初是为了降低新生儿呼吸窘迫综合征的发生率，随后是为了降低其他新生儿死亡率和发病率。由于它被广泛用作潜在早产的预防性治疗，关于双胎妊娠的相关问题仍存在争议，包括机会窗、使用时间、重复疗程、最佳给药至分娩间隔、剂量和皮质类固醇类型。因此，我们对双胎妊娠中产前皮质类固醇的使用进行了全面综述，强调上述问题，并试图为未来的研究和临床实践提供指导。
