St. Catherine Specialty Hospital, Zagreb, Croatia.
Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia.
Acta Clin Croat. 2022 Aug;61(2):248-256. doi: 10.20471/acc.2022.61.02.11.
The aim of this study was to compare the incidence of mild psychomotor delay in infants whose mothers were treated for thyroid dysfunction regardless of the cause during first trimester of pregnancy with those whose mothers did not use medications prenatally. The sample included 200 infants up to 4 months of age. Half of the infants were examined by a pediatric physiatrist, while the other half were chosen randomly from the primary pediatric clinic. Binary logistic regression was performed to assess the impact of factors on psychomotor delay. The model contained seven independent variables derived from bivariate analyses and clinical relevance. Results showed that the infant's chance of having psychomotor delay was 5.53 times higher if the mother had drug-compensated thyroid dysfunction. Younger gestational age increased the likelihood of delay 2.12 times each gestational week. The likelihood of psychomotor delay also rose by 1% 1 g of birth weight reduction. We found strong positive linear correlation between maternal drug-compensated thyroid dysfunction during pregnancy and psychomotor delay in infants, which has not been reported elsewhere. This differentiates an important and common prenatal risk factor and lays the foundation for faster initiation of habilitation of infants at risk. These insights provide a basis for planning the National Screening Program for Neurorisk Infants.
本研究旨在比较母亲在妊娠早期因任何原因接受甲状腺功能障碍治疗与未使用产前药物的孕妇所生婴儿轻度精神运动发育迟缓的发生率。样本包括 200 名年龄在 4 个月以下的婴儿。一半的婴儿由儿科物理治疗师检查，而另一半则随机从初级儿科诊所选择。采用二元逻辑回归评估因素对精神运动发育迟缓的影响。该模型包含来自双变量分析和临床相关性的七个独立变量。结果表明，如果母亲患有药物治疗的甲状腺功能障碍，婴儿出现精神运动发育迟缓的几率会增加 5.53 倍。每增加一周的孕龄，发生发育迟缓的可能性会增加 2.12 倍。出生体重每降低 1 克，发生发育迟缓的可能性也会增加 1%。我们发现，妊娠期间母亲的药物治疗甲状腺功能障碍与婴儿的精神运动发育迟缓之间存在强烈的正线性相关，这在其他地方尚未报道过。这区分了一个重要且常见的产前危险因素，并为有风险的婴儿更快开始康复奠定了基础。这些见解为国家神经发育风险婴儿筛查计划提供了依据。
