Lockard Trevor J, Swali Ritu N, Javid Whitley Melodi
Department of Dermatology, University of Nebraska Medical Center, Omaha, USA.
Department of Dermatology, Duke University, Durham, USA.
Cureus. 2023 Jan 18;15(1):e33937. doi: 10.7759/cureus.33937. eCollection 2023 Jan.
Hand-foot skin reaction (HFSR) is a documented cutaneous adverse reaction to tyrosine kinase inhibitor (TKI) chemotherapy. Cutaneous toxicities such as HFSR can be debilitating and may result in serious complications; however, continued chemotherapy is desirable to optimize the patient's odds of survival and tumor remission. We present a case of a 66-year-old male, with a history of metastatic renal clear cell carcinoma, who was diagnosed with grade 3 HFSR triggered by axitinib, a tyrosine kinase inhibitor. Our patient was able to expeditiously resume chemotherapy after temporary cessation of axitinib with concurrent application of topical steroids and keratolytics. Expedient return to life-prolonging chemotherapy is of great importance for patients with advanced malignancies; therefore, accurate diagnosis and prompt identification of the offending medication are critical to the management of this entity. We aim to increase the awareness of tyrosine kinase inhibitor-induced HFSR and review the diagnosis and current guidelines for management.
手足皮肤反应（HFSR）是一种已被记录的对酪氨酸激酶抑制剂（TKI）化疗的皮肤不良反应。诸如HFSR之类的皮肤毒性可能使人虚弱，并可能导致严重并发症；然而，继续化疗对于优化患者的生存几率和肿瘤缓解是可取的。我们报告一例66岁男性病例，该患者有转移性肾透明细胞癌病史，被诊断为由酪氨酸激酶抑制剂阿昔替尼引发的3级HFSR。我们的患者在暂时停用阿昔替尼并同时应用外用类固醇和角质剥脱剂后能够迅速恢复化疗。对于晚期恶性肿瘤患者，迅速恢复延长生命的化疗非常重要；因此，准确诊断和及时识别引起不良反应的药物对于该病症的管理至关重要。我们旨在提高对酪氨酸激酶抑制剂诱导的HFSR的认识，并回顾其诊断和当前的管理指南。
