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[自闭症与紧张症——临床方面]

[Autism and catatonia - Clinical aspects].

作者信息

Ruggieri Victor

机构信息

Fundación Garrahan, Buenos Aires, Argentina. E-mail:

出版信息

Medicina (B Aires). 2023 Mar;83 Suppl 2:43-47.

PMID:36820482
Abstract

Autism is a neurodevelopmental disorder characterized by a qualitative alteration in social interaction and communication, associated with restricted interests and stereotyped behaviors. It can be associated with medical problems such as epilepsy, gastrointestinal dysfunction, sleep disorders, other neurodevelopmental disorders such as language impairment, intellectual disability, sensory dysfunction, ADH/D, motor clumsiness, and/or neuropsychiatric disorders such as anxiety, depression, catatonia, schizophrenia, obsessive-compulsive disorders, behavioral and impulsive disorders, among others. Catatonia is recognized as a neuropsychiatric syndrome identified in all major mood and psychotic disorders, due to general medical conditions or as a syndrome not otherwise specified; this allows catatonia to be coded in the context of other psychiatric or neurodevelopmental disorders, such as obsessive-compulsive disorder or autism. It is characterized by abnormal motor, vocal, and behavioral symptoms, with impaired volition and vegetative function. It is estimated that approximately 8-11% of autistic people suffer from catatonia. It is probable that there is an underreporting of catatonia, especially in people with autism, due to the lack of alertness about it, the clinical heterogeneity and the similarity of many of its symptoms with manifestations of autism. Many times it can even express itself as a late autistic regression from puberty to adult life. Its neurobiological bases are still not clear and the treatment is based on the administration of bensodiazepines and electroconvulsive therapy although there is still a long way to go to investigate these issues.

摘要

自闭症是一种神经发育障碍,其特征是社交互动和沟通存在质性改变,并伴有兴趣受限和刻板行为。它可能与一些医学问题相关,如癫痫、胃肠功能障碍、睡眠障碍,还可能与其他神经发育障碍如语言障碍、智力残疾、感觉功能障碍、注意缺陷多动障碍、运动笨拙,和/或神经精神障碍如焦虑、抑郁、紧张症、精神分裂症、强迫症、行为和冲动障碍等有关。紧张症被认为是一种在所有主要情绪和精神障碍中都可识别的神经精神综合征,可由一般躯体状况引起,或作为未另作说明的综合征;这使得紧张症可在其他精神或神经发育障碍的背景下进行编码,如强迫症或自闭症。它的特征是运动、发声和行为症状异常,意志和植物神经功能受损。据估计,约8 - 11%的自闭症患者患有紧张症。由于对其缺乏警觉、临床异质性以及其许多症状与自闭症表现相似,紧张症很可能存在报告不足的情况,尤其是在自闭症患者中。很多时候,它甚至可以表现为从青春期到成年期的晚期自闭症退化。其神经生物学基础仍不清楚,治疗基于苯二氮䓬类药物的使用和电休克治疗,尽管在研究这些问题上仍有很长的路要走。

相似文献

1
[Autism and catatonia - Clinical aspects].[自闭症与紧张症——临床方面]
Medicina (B Aires). 2023 Mar;83 Suppl 2:43-47.
2
Onset of catatonia at puberty: electroconvulsive therapy response in two autistic adolescents.青春期出现紧张症:电抽搐治疗对两名自闭症青少年的疗效。
J ECT. 2010 Dec;26(4):274-7. doi: 10.1097/YCT.0b013e3181de332e.
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Catatonia in autistic disorder: a sign of comorbidity or variable expression?自闭症谱系障碍中的紧张症:共病迹象还是可变表达?
J Autism Dev Disord. 1991 Dec;21(4):517-28. doi: 10.1007/BF02206874.
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Self-injury in autism as an alternate sign of catatonia: implications for electroconvulsive therapy.自闭症患者的自伤行为作为紧张症的替代体征:对电抽搐治疗的影响。
Med Hypotheses. 2010 Jul;75(1):111-4. doi: 10.1016/j.mehy.2010.02.001. Epub 2010 Mar 3.
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Catatonia in autistic twins: role of electroconvulsive therapy.自闭症双胞胎中的紧张症:电休克治疗的作用
J ECT. 2007 Mar;23(1):21-2. doi: 10.1097/01.yct.0000263256.06421.7a.
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Catatonia in autism: a distinct subtype?自闭症中的紧张症:一种独特的亚型?
J Intellect Disabil Res. 2005 Jan;49(Pt 1):102-5. doi: 10.1111/j.1365-2788.2005.00666.x.
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Catatonia and autism: a historical review, with implications for electroconvulsive therapy.紧张症与自闭症:历史回顾及其对电休克治疗的启示
J ECT. 2009 Mar;25(1):19-22. doi: 10.1097/YCT.0b013e3181957363.
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Catatonia, autism, and ECT.紧张症、自闭症与电休克治疗
Dev Med Child Neurol. 1999 Dec;41(12):843-5. doi: 10.1017/s001216229900167x.
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Brief report: Electroconvulsive therapy for malignant catatonia in an autistic adolescent.简要报告:电抽搐治疗自闭症青少年的恶性紧张症。
Autism. 2010 Jul;14(4):349-58. doi: 10.1177/1362361309350135.
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The multiple faces of catatonia in autism spectrum disorders: descriptive clinical experience of 22 patients over 12 years.自闭症谱系障碍中紧张症的多种表现形式:12 年间 22 例患者的描述性临床经验。
Eur Child Adolesc Psychiatry. 2019 Apr;28(4):471-480. doi: 10.1007/s00787-018-1210-4. Epub 2018 Aug 1.