Ruggieri Victor
Fundación Garrahan, Buenos Aires, Argentina. E-mail:
Medicina (B Aires). 2023 Mar;83 Suppl 2:43-47.
Autism is a neurodevelopmental disorder characterized by a qualitative alteration in social interaction and communication, associated with restricted interests and stereotyped behaviors. It can be associated with medical problems such as epilepsy, gastrointestinal dysfunction, sleep disorders, other neurodevelopmental disorders such as language impairment, intellectual disability, sensory dysfunction, ADH/D, motor clumsiness, and/or neuropsychiatric disorders such as anxiety, depression, catatonia, schizophrenia, obsessive-compulsive disorders, behavioral and impulsive disorders, among others. Catatonia is recognized as a neuropsychiatric syndrome identified in all major mood and psychotic disorders, due to general medical conditions or as a syndrome not otherwise specified; this allows catatonia to be coded in the context of other psychiatric or neurodevelopmental disorders, such as obsessive-compulsive disorder or autism. It is characterized by abnormal motor, vocal, and behavioral symptoms, with impaired volition and vegetative function. It is estimated that approximately 8-11% of autistic people suffer from catatonia. It is probable that there is an underreporting of catatonia, especially in people with autism, due to the lack of alertness about it, the clinical heterogeneity and the similarity of many of its symptoms with manifestations of autism. Many times it can even express itself as a late autistic regression from puberty to adult life. Its neurobiological bases are still not clear and the treatment is based on the administration of bensodiazepines and electroconvulsive therapy although there is still a long way to go to investigate these issues.
自闭症是一种神经发育障碍,其特征是社交互动和沟通存在质性改变,并伴有兴趣受限和刻板行为。它可能与一些医学问题相关,如癫痫、胃肠功能障碍、睡眠障碍,还可能与其他神经发育障碍如语言障碍、智力残疾、感觉功能障碍、注意缺陷多动障碍、运动笨拙,和/或神经精神障碍如焦虑、抑郁、紧张症、精神分裂症、强迫症、行为和冲动障碍等有关。紧张症被认为是一种在所有主要情绪和精神障碍中都可识别的神经精神综合征,可由一般躯体状况引起,或作为未另作说明的综合征;这使得紧张症可在其他精神或神经发育障碍的背景下进行编码,如强迫症或自闭症。它的特征是运动、发声和行为症状异常,意志和植物神经功能受损。据估计,约8 - 11%的自闭症患者患有紧张症。由于对其缺乏警觉、临床异质性以及其许多症状与自闭症表现相似,紧张症很可能存在报告不足的情况,尤其是在自闭症患者中。很多时候,它甚至可以表现为从青春期到成年期的晚期自闭症退化。其神经生物学基础仍不清楚,治疗基于苯二氮䓬类药物的使用和电休克治疗,尽管在研究这些问题上仍有很长的路要走。