Treatment of paradoxical eczematous eruption in psoriasis treated with secukinumab: A case report.

RATIONALE

Eczematous eruption is an increasingly recognized form of drug-related eruption, typically reported in association with interleukin 17 (IL-17)A inhibitors. However, severe paradoxical eczematous eruption due to IL-17A inhibitors has been rarely reported. Herein, we reported a case of a man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated.

PATIENT CONCERNS

We reported a case of a 20-year-old man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated. A skin biopsy was performed. It revealed spongiotic dermatitis consistent with eczematous reaction. Direct and indirect immunofluorescence assays were negative.

DIAGNOSES

He was diagnosed with eczematous eruption.

INTERVENTIONS

Discontinuation of secukinumab and administration of cyclosporine and prednisone were considered.

OUTCOMES

Significant improvement was observed, with no adverse events.

CONCLUSION

Our case shows that eczematous eruption can paradoxically occur in patients on IL-17A inhibitors and this report is expected to increase awareness of the rising number of cutaneous eruptions related to biological agents.