Taniyadukkam Vijisha, Jose Jobin, Maliyakkal Naseer, Beeran Asmy Appadath, Almoyad Muhammad Ali Abdullah, Aleya Lotfi, Bandiwadekar Akshay
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to Be University), Mangalore, 575018, Karnataka, India.
Department of Basic Medical Sciences, College of Applied Medical Sciences in Khamis Mushait, King Khalid University, Abha, Kingdom of Saudi Arabia.
Environ Sci Pollut Res Int. 2023 Apr;30(18):51782-51791. doi: 10.1007/s11356-023-25947-0. Epub 2023 Feb 23.
More research is needed to understand the benefits of environmentally safe and human-friendly herbal-based sunscreen agents against ultraviolet (UV) radiation. Because of the toxicity of synthetic chemicals in photoprotective agents, researchers were increasingly focusing on herbal photoprotective formulations. The photoprotective agent's skin retention can be considerably improved by forming solid lipid nanoparticles (SLN). The study's objective is to evaluate the photoprotective potential of sunscreen cream containing spinach (Spinacia oleracea)-loaded SLN. A solvent emulsification technique was used to develop the spinach-loaded SLN. The various characterization techniques of the developed SLN were performed. Out of all the formulations, the optimized one was fitted into cream and estimated for its photoprotective action. The images obtained from scanning electron microscopy (SEM) revealed the morphological characteristics of the prepared SLN. The sunscreen cream's viscosity, spreadability, extrudability, and release rate were within acceptable limits. The formulation's in vitro and in vivo sun protection factor (SPF) was reported to be 15.9 and 14.75, respectively. The results indicated that the prepared formulation possesses good photoprotective action. The accelerated stability tests were carried out with no noticeable changes in the parameters. Our work demonstrated the possibility of using spinach-loaded SLN as a photoprotective agent in cosmetic formulations.
需要更多研究来了解环境安全且对人体友好的草本防晒霜对紫外线（UV）辐射的防护效果。由于光防护剂中合成化学物质的毒性，研究人员越来越关注草本光防护配方。通过形成固体脂质纳米粒（SLN），可显著提高光防护剂在皮肤中的留存率。本研究的目的是评估含有负载菠菜（菠菜属）的SLN的防晒霜的光防护潜力。采用溶剂乳化技术制备负载菠菜的SLN。对所制备的SLN进行了各种表征技术研究。在所有配方中，将优化后的配方制成乳膏，并评估其光防护作用。扫描电子显微镜（SEM）获得的图像揭示了所制备SLN的形态特征。该防晒霜乳膏的粘度、铺展性、挤出性和释放速率均在可接受范围内。该配方的体外和体内防晒系数（SPF）分别为15.9和14.75。结果表明，所制备的配方具有良好的光防护作用。进行了加速稳定性试验，各项参数无明显变化。我们的工作证明了在化妆品配方中使用负载菠菜的SLN作为光防护剂的可能性。
