Ruiz-Castell Maria, Le Coroller Gwenaëlle, Pexaras Achilleas, Ciprián Giovana M, Fagherazzi Guy, Bohn Torsten, Maitre Léa, Sunyer Jordi, Appenzeller Brice M R
Department of Precision Health, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.
Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445 Strassen, Luxembourg.
Environ Int. 2023 Mar;173:107780. doi: 10.1016/j.envint.2023.107780. Epub 2023 Jan 26.
Throughout life individuals are exposed to a large array of diverse environmental exposures (exposome). Hair analyses can assess chronic exposure to a large number of chemicals with less intra-variability than urine and blood. This is essential for studies that aim to achieve a global vision of the exposome. We aimed at characterizing the adult exposome by describing 175 environmental exposures and correlation patterns between and within exposure groups. A subsample of participants of the European Health Examination Survey, covering information on exposure to chemical pollutants in hair samples, were included in the present analysis (N = 442). Concentrations of micronutrients, lifestyle, home environment and socioeconomic information completed the exposome description and were obtained through blood analyses and questionnaires. We detected 29 persistent and non-persistent chemical pollutants in more than 70% of hair samples. Compared to women, men had higher concentrations of pesticides, lower concentrations of micronutrients (with the exception of vitamin A), and presented higher alcohol consumption. Across all exposures, a low median absolute correlation was found, 0.05 (5th - 95th centiles = 0.10, 0.20). We observed higher correlations and median correlations within exposure groups than between groups of exposure. The highest median correlation was observed between plasticizers (bisphenol A and S) in both men (0.50) and women (0.31). A 70% and 95% of cumulative variance was explained by 37 and 73 principal components respectively. We found a wide range of chemical exposures in hair samples of men and women. The adult exposome was complex and multidimensional. Future exposome studies should include hair as a matrix for characterizing exposure to multiple environmental chemicals.
在人的一生中，个体暴露于大量多样的环境暴露因素（暴露组）中。头发分析可以评估对大量化学物质的长期暴露，与尿液和血液相比，其个体内变异性较小。这对于旨在全面了解暴露组的研究至关重要。我们旨在通过描述175种环境暴露因素以及暴露组之间和组内的相关模式来刻画成年人的暴露组。本分析纳入了欧洲健康检查调查参与者的一个子样本，该样本涵盖了头发样本中化学污染物暴露的信息（N = 442）。通过血液分析和问卷调查获得的微量营养素浓度、生活方式、家庭环境和社会经济信息完善了暴露组描述。我们在70%以上的头发样本中检测到29种持久性和非持久性化学污染物。与女性相比，男性的农药浓度较高，微量营养素浓度较低（维生素A除外），且酒精摄入量较高。在所有暴露因素中，发现中位数绝对相关性较低，为0.05（第5百分位数 - 第95百分位数 = 0.10，0.20）。我们观察到暴露组内的相关性和中位数相关性高于组间。在男性（0.50）和女性（0.31）中，增塑剂（双酚A和S）之间的中位数相关性最高。分别有37个和73个主成分解释了70%和95%的累积方差。我们在男性和女性的头发样本中发现了广泛的化学暴露。成年人的暴露组是复杂且多维度的。未来的暴露组研究应将头发作为一种基质，用于刻画对多种环境化学物质的暴露情况。
