Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Neurology Department, Turkey.
Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Neurology Department, Turkey.
Neurophysiol Clin. 2023 Feb;53(1):102846. doi: 10.1016/j.neucli.2023.102846. Epub 2023 Feb 21.
In this study, our aim was to demonstrate the effect of sleep deprivation, short sleep, and awakening on photoparoxysmal responses (PPR) and eyelid myoclonia (EM) in patients with Epilepsy with Eyelid Myoclonia (E-EM).
E-EM patients with at least 1 year of follow-up in our clinic were included in the study. Video EEG(v-EEG) analyses were divided into three periods of wakefulness, sleep, and awakening. The PPR and onset of EMs were investigated.
32 patients met the study criteria, of which 56.3% (n = 18) were male. The mean age at disease onset was 7.7 ± 4.1 years. The mean age at EEG recording was 12.4 ± 4.0 years. EM was observed only on awakening in 78.1% of patients (n = 22), of which it was seen only during intermittent photic stimulation (IPS) in 43.7% (n = 14). Eye closure (EC) sensitivity was detected in all patients. The proportion of patients with a PPR was significantly higher on awakening than before sleep (p = 0.01).
This study showed that EM is most prominent and sometimes can only be detected in the awakening period in E-EM. In order to detect E-EM, v-EEG recordings including both pre-sleep and post-sleep wakefulness periods should be recorded, with intermittent photic stimulation performed in both periods.
本研究旨在探讨睡眠剥夺、短睡眠和觉醒对癫痫伴眼睑肌阵挛（E-EM）患者光惊反射（PPR）和眼睑肌阵挛（EM）的影响。
本研究纳入了在我院接受至少 1 年随访的 E-EM 患者。视频脑电图（v-EEG）分析分为清醒期、睡眠期和觉醒期三个阶段。研究调查了 PPR 和 EM 的发作情况。
32 例患者符合研究标准，其中 56.3%（n=18）为男性。疾病发作的平均年龄为 7.7±4.1 岁。进行脑电图记录的平均年龄为 12.4±4.0 岁。78.1%（n=22）的患者仅在觉醒时观察到 EM，其中 43.7%（n=14）仅在间歇性光刺激（IPS）期间观察到 EM。所有患者均检测到闭眼（EC）敏感性。觉醒时出现 PPR 的患者比例明显高于睡眠前（p=0.01）。
本研究表明，在 E-EM 中，EM 最突出，有时仅在觉醒期检测到。为了检测 E-EM，应记录包括睡眠前和睡眠后觉醒期的 v-EEG 记录，并在两个时期进行间歇性光刺激。
