Boelig Rupsa C
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, 833 Chestnut Street, Level 1, Philadelphia, PA 19107, USA; Department of Clinical Pharmacology and Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Obstet Gynecol Clin North Am. 2023 Mar;50(1):101-107. doi: 10.1016/j.ogc.2022.10.004.
Specifically, meta-analyses of randomized trials demonstrate that vaginal progesterone reduces the risk of preterm birth in selected high-risk singleton pregnancies. 17-OHPC may also reduce the risk of recurrent preterm birth in singletons. Finally, one trial suggests that vaginal progesterone may also be beneficial in improving live birth rates in singletons with prior miscarriages and early pregnancy bleeding.
具体而言，随机试验的荟萃分析表明，阴道用黄体酮可降低特定高危单胎妊娠的早产风险。17-羟孕酮也可能降低单胎复发性早产的风险。最后，一项试验表明，阴道用黄体酮可能还有助于提高有既往流产和孕早期出血史的单胎妊娠的活产率。
