Sethi Sanjeev, Madden Benjamin
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic Proteomics Core, Mayo Clinic, Rochester, Minnesota, USA.
Kidney Int. 2023 Mar;103(3):469-472. doi: 10.1016/j.kint.2023.01.003.
Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel "putative" antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.
膜性肾病（MN）的特征是免疫复合物沿肾小球基底膜在肾小球上皮下沉积。这些免疫复合物包括IgG及相应的靶抗原。最近的进展已导致发现了新的MN靶抗原。在这项由卡扎等人开展的研究中，提出了7种新的“假定”抗原。现在大约90%的MN病例中可识别出靶抗原。除了描述另外10种新的假定抗原外，我们还提出了一种评估MN中靶抗原的实用算法。
