改善术后睡眠质量的药物治疗：系统评价和网络荟萃分析方案。
Pharmacotherapy for improving postoperative sleep quality: a protocol for a systematic review and network meta-analysis.
机构信息
Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Anaesthesiology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
出版信息
BMJ Open. 2023 Feb 23;13(2):e069724. doi: 10.1136/bmjopen-2022-069724.
INTRODUCTION
Improving the quality of sleep may promote enhanced recovery in surgical patients. In addition to controversial or conflicting study conclusions, the current clinical studies on pharmacotherapy for improving postoperative sleep quality are mostly limited to evaluating the effect of a specific drug or supplement compared with placebo, and they lack comparisons between drugs or supplements. Therefore, we plan to conduct a systematic review and network meta-analysis to compare the efficacy of different drugs or supplements for improving postoperative sleep quality.
METHODS AND ANALYSIS
We will search the MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CNKI and Wanfang databases from the dates of their inception to December 2022. We will only include randomised controlled trials, irrespective of language and publication status. The primary outcome is postoperative sleep quality assessed by any validated tools or polysomnography. We will assess the quality of all included trials according to version 2 of the Cochrane risk-of-bias tool for randomised trials. We will use the GeMTC package of R software to perform direct and indirect comparisons via a Bayesian framework using a random-effects model. We will use the Confidence in Network Meta-Analysis approach to evaluate the quality of evidence.
ETHICS AND DISSEMINATION
Ethical approval is not required for this protocol because we will only be pooling published data. We plan to submit our review to academic conferences and peer-reviewed academic journals.
PROSPERO REGISTRATION NUMBER
CRD42022356508.
简介
改善睡眠质量可能有助于促进手术患者的康复。除了结论存在争议或相互矛盾的研究外，目前关于改善术后睡眠质量的药物治疗的临床研究大多仅限于评估特定药物或补充剂与安慰剂相比的效果，并且缺乏药物或补充剂之间的比较。因此，我们计划进行系统评价和网络荟萃分析，以比较改善术后睡眠质量的不同药物或补充剂的疗效。
方法和分析
我们将从各数据库的创建日期到 2022 年 12 月检索 MEDLINE、Embase、Cochrane 中央对照试验注册库、中国知网和万方数据库。我们将只纳入随机对照试验，无论语言和出版状态如何。主要结局是使用任何经过验证的工具或多导睡眠图评估术后睡眠质量。我们将根据随机对照试验的 Cochrane 偏倚风险工具版本 2 评估所有纳入试验的质量。我们将使用 R 软件的 GeMTC 包通过贝叶斯框架使用随机效应模型进行直接和间接比较。我们将使用网络荟萃分析置信度方法来评估证据质量。
伦理和传播
由于我们将只汇总已发表的数据，因此本方案不需要伦理批准。我们计划将我们的综述提交给学术会议和同行评议的学术期刊。
PROSPERO 注册号：CRD42022356508。
Zotero 插件