Department of Pharmacy, Kariya Toyota General Hospital, Japan.
Department of Clinical Laboratory, Kariya Toyota General Hospital, Japan.
Intern Med. 2023 Oct 1;62(19):2919-2922. doi: 10.2169/internalmedicine.1141-22. Epub 2023 Feb 22.
We herein report a case of peritoneal dialysis-associated peritonitis caused by Lysinibacillus sphaericus in a 40s-year-old patient. Treatment was initiated with intermittent intraperitoneal cefazolin and ceftazidime. Later, both peritoneal dialysate and blood cultures detected L. sphaericus, so the antibiotic was changed to ampicillin (ABPC). The patient was treated with a combination of intraperitoneal intermittent and intravenous ABPC for 7 days, followed by 14 days of amoxicillin. The patient experienced no adverse events and no recurrence for 30 days. The patient had four dogs, and the infection was deemed likely to have been caused by environmental contamination and inadequate catheter replacement.
我们在此报告一例由球形赖氨酸芽孢杆菌引起的 40 多岁患者腹膜透析相关性腹膜炎。治疗开始时采用间歇性腹腔头孢唑林和头孢他啶。后来，腹膜透析液和血液培养均检测到球形赖氨酸芽孢杆菌，因此将抗生素改为氨苄西林（ABPC）。患者接受了 7 天的腹腔间歇性和静脉内 ABPC 联合治疗，随后又接受了 14 天的阿莫西林治疗。患者未发生不良反应，30 天内无复发。患者有 4 只狗，感染可能是由环境污染和导管更换不充分引起的。
