Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
Department of Ophthalmology, AIN Woman`s Hospital, Incheon, Republic of Korea.
Front Endocrinol (Lausanne). 2023 Feb 6;13:1080204. doi: 10.3389/fendo.2022.1080204. eCollection 2022.
Graves' orbitopathy (GO) is a complex autoimmune disorder of the orbit that causes the eye to appear disfigured. GO is typically associated with Graves' disease, an inflammatory autoimmune condition that is caused by thyrotropin receptor autoantibodies. Although our knowledge of the pathophysiology of GO has improved, its exact pathogenesis remains unclear. Some patients suffer from disfigurement, double vision, and even vision loss rather than hyperthyroidism. The disease severity and activity prompt different treatments, as the signs of GO are heterogeneous, so their management can be very complex. Despite medical advances, the first-line treatment for moderate-to-severe active GO is still glucocorticoids, while surgery can be critical for the treatment of chronic inactive GO. Surgery is sometimes required in the acute phase of the disease when there is an immediate risk to vision, such as in dysthyroid optic neuropathy. Most surgeries for GO are rehabilitative and subdivided into three categories: decompression, strabismus repair, and lid surgery. This review is a basic overview of the field, with up-to-date knowledge of the surgical techniques for GO. We review and summarize recent literature on the advances in surgery for GO to provide up-to-date insights on the optimal surgical treatment for GO.
格雷夫斯眼病(GO)是一种复杂的眼眶自身免疫性疾病,可导致眼睛外观畸形。GO 通常与 Graves 病有关,后者是一种炎症性自身免疫性疾病,由促甲状腺素受体自身抗体引起。尽管我们对 GO 的病理生理学有了更多的了解,但确切的发病机制仍不清楚。一些患者患有畸形、复视,甚至视力丧失,而不是甲状腺功能亢进。疾病的严重程度和活动度提示需要不同的治疗方法,因为 GO 的体征是异质的,因此其管理可能非常复杂。尽管医学取得了进步,但中重度活动性 GO 的一线治疗方法仍然是糖皮质激素,而手术对于治疗慢性非活动性 GO 至关重要。当存在立即威胁视力的风险时,如在甲状腺相关的视神经病变中,疾病的急性期有时需要手术。GO 的大多数手术都是康复性的,可分为三类:减压、斜视矫正和眼睑手术。这篇综述是对该领域的基本概述,包含了 GO 手术技术的最新知识。我们回顾和总结了 GO 手术方面的最新文献,为 GO 的最佳手术治疗提供了最新的见解。