Qazi Taimoor H, Burdick Jason A
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Biomater Biosyst. 2021 Jan 27;1:100008. doi: 10.1016/j.bbiosy.2021.100008. eCollection 2021 Mar.
Granular hydrogels, formed by the packing of hydrogel microparticles (microgels), are emerging to support the endogenous repair of injured tissues by guiding local cell behavior. In contrast to traditional pre-formed scaffolds and bulk hydrogels, granular hydrogels offer exciting features such as injectability, inherent porosity, and the potential delivery of biologics. Further, granular hydrogel design allows for the tuning of constituent microgel properties and the mixing of discrete microgel populations. This modularity allows the creation of multifunctional granular hydrogels that promote cell recruitment, guide extracellular matrix deposition, and stimulate tissue growth to drive endogenous repair.
由水凝胶微粒（微凝胶）堆积形成的粒状水凝胶正在兴起，通过引导局部细胞行为来支持受损组织的内源性修复。与传统的预制支架和块状水凝胶相比，粒状水凝胶具有诸如可注射性、固有孔隙率以及生物制剂潜在递送等令人兴奋的特性。此外，粒状水凝胶的设计允许调节组成微凝胶的特性以及混合离散的微凝胶群体。这种模块化使得能够创建促进细胞募集、引导细胞外基质沉积并刺激组织生长以驱动内源性修复的多功能粒状水凝胶。
