Laboratory of Food Safety, College of Food Science and Engineering, Ocean University of China, Qingdao, China.
Department of Pathology, Microbiology and Immunology and Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Crit Rev Food Sci Nutr. 2023;63(10):1314-1338. doi: 10.1080/10408398.2023.2181755. Epub 2023 Feb 24.
Seafoods are fashionable delicacies with high nutritional values and culinary properties, while seafood belongs to worldwide common food allergens. In recent years, many seafood allergens have been identified, while the diversity of various seafood species give a great challenge in identifying and characterizing seafood allergens, mapping IgE-binding epitopes and allergen immunotherapy development, which are critical for allergy diagnostics and immunotherapy treatments. This paper reviewed the recent progress on seafood (fish, crustacean, and mollusk) allergens, IgE-binding epitopes and allergen immunotherapy for seafood allergy. In recent years, many newly identified seafood allergens were reported, this work concluded the current situation of seafood allergen identification and designation by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Sub-Committee. Moreover, this review represented the recent advances in identifying the IgE-binding epitopes of seafood allergens, which were helpful to the diagnosis, prevention and treatment for seafood allergy. Furthermore, the allergen immunotherapy could alleviate seafood allergy and provide promising approaches for seafood allergy treatment. This review represents the recent advances and future outlook on seafood allergen identification, IgE-binding epitope mapping and allergen immunotherapy strategies for seafood allergy prevention and treatment.
海鲜是具有高营养价值和烹饪特性的时尚美食，而海鲜属于全球常见的食物过敏原。近年来，已经鉴定出许多海鲜过敏原，而各种海鲜物种的多样性给鉴定和表征海鲜过敏原、绘制 IgE 结合表位和过敏原免疫治疗的发展带来了巨大的挑战，这些对于过敏诊断和免疫治疗都至关重要。本文综述了海鲜（鱼、甲壳类和软体动物）过敏原、IgE 结合表位和海鲜过敏的过敏原免疫治疗的最新进展。近年来，许多新鉴定的海鲜过敏原被报道，本文总结了世界卫生组织（WHO）/国际免疫学会联合会（IUIS）过敏原命名子委员会当前海鲜过敏原鉴定和指定的现状。此外，本综述还介绍了鉴定海鲜过敏原 IgE 结合表位的最新进展，这有助于海鲜过敏的诊断、预防和治疗。此外，过敏原免疫疗法可以减轻海鲜过敏，并为海鲜过敏治疗提供有前景的方法。本文综述了海鲜过敏原鉴定、IgE 结合表位作图和过敏原免疫治疗策略在海鲜过敏预防和治疗方面的最新进展和未来展望。
